Trait
SNPs associated with Total cholesterol
2769 genetic variants across 551 genes have been associated with Total cholesterol in published research. Key genes include A1CF, ABCA1, ABCA6.
Associated variants2,769 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs964184 | APOA5 | GWAS association (p=6.0e-57) | Meta-analysis |
| rs7528419 | CELSR2 | GWAS association (p=9.9e-324) | Meta-analysis |
| rs5985519 | — | GWAS association (p=4.0e-184) | Meta-analysis |
| rs34065661 | CETP | GWAS association (p=1.0e-23) | Meta-analysis |
| rs762517 | G6PD | GWAS association (p=8.0e-18) | Meta-analysis |
| rs2238675 | — | GWAS association (p=1.0e-13) | Meta-analysis |
| rs73015020 | — | GWAS association (p=2.0e-12) | Meta-analysis |
| rs2230488 | RPS6KA3 | GWAS association (p=9.0e-12) | Meta-analysis |
| rs35143646 | ARSL | GWAS association (p=1.0e-11) | Meta-analysis |
| rs33918808 | ABCA1 | GWAS association (p=2.0e-11) | Meta-analysis |
| rs661665 | APOB | GWAS association (p=3.0e-11) | Meta-analysis |
| rs1802288 | TSPAN6 | GWAS association (p=3.0e-11) | Meta-analysis |
| rs61483465 | — | GWAS association (p=7.0e-11) | Meta-analysis |
| rs115069429 | SLC22A3 | GWAS association (p=4.0e-09) | Meta-analysis |
| rs138534124 | KANK2 | GWAS association (p=8.0e-09) | Meta-analysis |
| rs1250229 | — | GWAS association (p=1.0e-08) | Meta-analysis |
| rs2235776 | — | GWAS association (p=3.0e-08) | Meta-analysis |
| rs7412 | APOE | GWAS association (p=0.0e+00) | Meta-analysis |
| rs12740374 | CELSR2 | GWAS association (p=0.0e+00) | Meta-analysis |
| rs28362286 | PCSK9 | GWAS association (p=1.0e-287) | Meta-analysis |
| rs12151108 | — | GWAS association (p=8.0e-101) | Meta-analysis |
| rs4420638 | APOC1 | GWAS association (p=5.0e-111) | Major Consortium Study |
| rs6511720 | LDLR | GWAS association (p=7.0e-97) | Major Consortium Study |
| rs62117160 | — | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs365653 | — | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs142042446 | — | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs7254892 | — | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs34095326 | — | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs11668327 | — | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs769449 | APOE | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs141622900 | — | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs12721109 | — | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs28601761 | — | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs73015024 | — | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs429358 | APOE | GWAS association (p=9.9e-324) | Major Consortium Study |
| rs61679753 | TOMM40 | GWAS association (p=9.9e-324) | Major Consortium Study |
| rs4299376 | ABCG8 | GWAS association (p=4.0e-45) | Major Consortium Study |
| rs8106503 | — | GWAS association (p=2.0e-281) | Major Consortium Study |
| rs28399654 | — | GWAS association (p=8.0e-281) | Major Consortium Study |
| rs6859 | NECTIN2 | GWAS association (p=3.0e-236) | Major Consortium Study |
| rs10455872 | LPA | GWAS association (p=5.0e-221) | Major Consortium Study |
| rs28399637 | — | GWAS association (p=4.0e-215) | Major Consortium Study |
| rs72658867 | LDLR | GWAS association (p=9.0e-195) | Major Consortium Study |
| rs60049679 | — | GWAS association (p=4.0e-191) | Major Consortium Study |
| rs76366838 | — | GWAS association (p=5.0e-183) | Major Consortium Study |
| rs12721051 | APOC1 | GWAS association (p=1.0e-179) | Major Consortium Study |
| rs17216525 | — | GWAS association (p=5.0e-178) | Major Consortium Study |
| rs10166144 | — | GWAS association (p=4.0e-173) | Major Consortium Study |
| rs7259004 | APOC1P1 | GWAS association (p=4.0e-173) | Major Consortium Study |
| rs183130 | CETP | GWAS association (p=3.0e-161) | Major Consortium Study |
| rs71352239 | — | GWAS association (p=2.0e-158) | Major Consortium Study |
| rs2954038 | — | GWAS association (p=2.0e-154) | Major Consortium Study |
| rs780094 | GCKR | GWAS association (p=7.0e-153) | Major Consortium Study |
| rs74617384 | — | GWAS association (p=7.0e-151) | Major Consortium Study |
| rs507666 | ABO | GWAS association (p=4.0e-149) | Major Consortium Study |
| rs1883711 | — | GWAS association (p=1.0e-147) | Major Consortium Study |
| rs6511721 | — | GWAS association (p=2.0e-135) | Major Consortium Study |
| rs77960347 | LIPG | GWAS association (p=2.0e-132) | Major Consortium Study |
| rs77542162 | ABCA6 | GWAS association (p=2.0e-130) | Major Consortium Study |
| rs12052058 | — | GWAS association (p=3.0e-129) | Major Consortium Study |
| rs2278426 | ANGPTL8 | GWAS association (p=2.0e-123) | Major Consortium Study |
| rs73013159 | — | GWAS association (p=5.0e-123) | Major Consortium Study |
| rs550619 | — | GWAS association (p=7.0e-123) | Major Consortium Study |
| rs41289512 | — | GWAS association (p=8.0e-122) | Major Consortium Study |
| rs9297994 | — | GWAS association (p=4.0e-117) | Major Consortium Study |
| rs2304130 | ZNF101 | GWAS association (p=2.0e-15) | Major Consortium Study |
| rs995000 | — | GWAS association (p=6.0e-112) | Major Consortium Study |
| rs2266788 | ZPR1 | GWAS association (p=1.0e-108) | Major Consortium Study |
| rs12130333 | — | GWAS association (p=4.0e-107) | Major Consortium Study |
| rs73015030 | — | GWAS association (p=4.0e-107) | Major Consortium Study |
| rs62116778 | — | GWAS association (p=5.0e-106) | Major Consortium Study |
| rs6698843 | CELSR2 | GWAS association (p=6.0e-105) | Major Consortium Study |
| rs4970829 | — | GWAS association (p=2.0e-103) | Major Consortium Study |
| rs2000999 | HPR | GWAS association (p=3.0e-24) | Major Consortium Study |
| rs3135506 | APOA5 | GWAS association (p=6.0e-103) | Major Consortium Study |
| rs533617 | APOB | GWAS association (p=1.0e-102) | Major Consortium Study |
| rs5471 | HP | GWAS association (p=6.0e-102) | Major Consortium Study |
| rs115478735 | ABO | GWAS association (p=6.0e-101) | Major Consortium Study |
| rs7188 | — | GWAS association (p=4.0e-100) | Major Consortium Study |
| rs117310449 | — | GWAS association (p=2.0e-98) | Major Consortium Study |
| rs2575876 | ABCA1 | GWAS association (p=4.0e-97) | Major Consortium Study |
| rs2207132 | — | GWAS association (p=9.0e-97) | Major Consortium Study |
| rs585362 | — | GWAS association (p=2.0e-93) | Major Consortium Study |
| rs144261139 | — | GWAS association (p=4.0e-90) | Major Consortium Study |
| rs12691088 | — | GWAS association (p=7.0e-89) | Major Consortium Study |
| rs28362263 | PCSK9 | GWAS association (p=1.0e-88) | Major Consortium Study |
| rs6689 | HLA-DQB1 | GWAS association (p=2.0e-87) | Major Consortium Study |
| rs532436 | ABO | GWAS association (p=2.0e-87) | Major Consortium Study |
| rs55660224 | MYBPHL | GWAS association (p=6.0e-87) | Major Consortium Study |
| rs754340 | — | GWAS association (p=1.0e-85) | Major Consortium Study |
| rs12691202 | APOB | GWAS association (p=4.0e-85) | Major Consortium Study |
| rs1800961 | HNF4A | GWAS association (p=6.0e-13) | Major Consortium Study |
| rs11855284 | — | GWAS association (p=2.0e-84) | Major Consortium Study |
| rs514230 | LINC01132 | GWAS association (p=5.0e-14) | Major Consortium Study |
| rs11206510 | PCSK9 | GWAS association (p=5.0e-84) | Major Consortium Study |
| rs983309 | — | GWAS association (p=2.0e-83) | Major Consortium Study |
| rs17725246 | — | GWAS association (p=4.0e-83) | Major Consortium Study |
| rs72660594 | — | GWAS association (p=8.0e-79) | Major Consortium Study |
| rs7350789 | — | GWAS association (p=4.0e-78) | Major Consortium Study |
| rs2618566 | — | GWAS association (p=6.0e-74) | Major Consortium Study |
Showing the top 100 of 2,769 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.