LPA

lipoprotein(a)

Summary

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

Known Variants212 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs545703211	6:160,952,215	G/A	—	—
rs186413938	6:160,952,780	C/T	—	benign
rs765700553	6:160,952,811	G/A	—	uncertain significance
rs3124784	6:160,952,838	A/G	—	benign
rs373314930	6:160,952,903	A/G	—	uncertain significance
rs1425618674	6:160,953,681	C/T	—	uncertain significance
rs189377046	6:160,958,929	C/T	—	uncertain significance
rs6919346	6:160,960,359	T/C	intron variant	—
rs781720212	6:160,961,069	G/A	—	likely benign
rs201944278	6:160,961,111	G/A	—	uncertain significance
rs759236772	6:160,961,135	T/C	—	uncertain significance
rs3798220	6:160,961,137	T/C	missense variant	benign
rs2483867028	6:160,961,172	G/C	—	uncertain significance
rs1777958774	6:160,961,215	C/G	—	uncertain significance
rs769068995	6:160,962,152	G/A	—	uncertain significance
rs200086599	6:160,962,185	A/G	—	likely benign
rs2483869925	6:160,962,211	A/G	—	uncertain significance
rs7767084	6:160,962,503	T/C	intron variant	—
rs41265936	6:160,963,774	C/T	—	uncertain significance
rs200831181	6:160,963,789	G/A	—	uncertain significance
rs771057576	6:160,963,801	G/A	—	uncertain significance
rs2483880878	6:160,966,490	A/G	—	uncertain significance
rs575752328	6:160,966,537	T/C	—	uncertain significance
rs41264856	6:160,966,541	T/C	—	likely benign
rs1778053672	6:160,966,553	G/C	—	uncertain significance
rs139145675	6:160,966,559	G/A	—	likely benign
rs368260113	6:160,968,823	T/A	—	uncertain significance
rs200506481	6:160,968,841	A/G	—	likely benign
rs1778099101	6:160,968,913	C/T	—	uncertain significance
rs369510777	6:160,968,918	A/G	—	uncertain significance
rs779343223	6:160,968,967	A/T	—	uncertain significance
rs41264848	6:160,968,968	G/A	—	likely benign
rs41264338	6:160,969,539	A/T	—	uncertain significance
rs41267811	6:160,969,584	G/C	—	uncertain significance
rs1801693	6:160,969,629	G/A	—	benign
rs774456131	6:160,969,654	C/A	—	uncertain significance
rs763635835	6:160,969,672	A/C	—	uncertain significance
rs143431368	6:160,969,693	T/C	—	benign
rs10755578	6:160,969,738	C/G	intron variant	—
rs12207195	6:160,974,578	G/A	intron variant	—
rs561110147	6:160,976,262	T/C	—	—
rs73014164	6:160,976,620	C/T	intron variant	—
rs1778258189	6:160,977,123	G/A	—	uncertain significance
rs776662773	6:160,977,156	C/T	—	uncertain significance
rs1778259370	6:160,977,183	C/T	—	uncertain significance
rs933958432	6:160,978,502	T/C	—	uncertain significance
rs765076734	6:160,978,517	T/C	—	uncertain significance
rs775305075	6:160,978,557	G/T	—	uncertain significance
rs2483920300	6:160,978,575	G/T	—	uncertain significance
rs760679789	6:160,978,581	T/C	—	uncertain significance
rs375415625	6:160,978,583	C/T	—	uncertain significance
rs763818436	6:160,978,584	A/C	—	uncertain significance
rs6415084	6:160,980,330	T/C	intron variant	—
rs146871152	6:160,984,637	C/T	intron variant	—
rs9365172	6:160,985,035	C/A	intron variant	—
rs115689904	6:160,985,500	C/A	intron variant	—
rs118039278	6:160,985,526	G/A	intron variant	—
rs190068306	6:160,986,280	G/A	intron variant	—
rs543895576	6:160,987,403	A/G	—	—
rs369771011	6:160,988,561	A/G	—	—
rs9355291	6:160,989,288	C/T	intron variant	—
rs189132280	6:160,992,093	A/G	intron variant	—
rs145274579	6:160,996,139	C/T	intron variant	—
rs41267813	6:160,998,199	G/A	missense variant	—
rs746819045	6:160,998,267	C/G	—	uncertain significance
rs769200592	6:160,998,279	C/T	—	uncertain significance
rs201290459	6:160,998,312	C/A	—	likely benign
rs200920617	6:160,999,547	T/C	—	likely benign
rs781183372	6:160,999,570	C/T	—	uncertain significance
rs755904089	6:160,999,577	G/T	—	uncertain significance
rs373234964	6:160,999,623	G/A	—	uncertain significance
rs2483995732	6:160,999,655	C/G	—	uncertain significance
rs201378726	6:160,999,692	C/T	—	uncertain significance
rs776834258	6:160,999,713	C/T	—	uncertain significance
rs749022182	6:160,999,717	A/C	—	uncertain significance
rs1463071182	6:160,999,731	A/G	—	uncertain significance
rs932631509	6:161,001,428	T/C	—	—
rs571848809	6:161,005,388	G/T	—	—
rs191555775	6:161,005,389	A/T	intron variant	—
rs55730499	6:161,005,610	C/T	intron variant	—
rs41272114	6:161,006,077	T/C	—	likely benign
rs76144756	6:161,006,084	G/A	missense variant	—
rs41272112	6:161,006,105	C/T	missense variant	—
rs370130400	6:161,006,106	G/A	—	uncertain significance
rs771836727	6:161,006,114	T/A	—	uncertain significance
rs770419679	6:161,006,127	A/G	—	uncertain significance
rs200436229	6:161,006,132	C/A	—	uncertain significance
rs2484018960	6:161,006,133	A/G	—	uncertain significance
rs1255326656	6:161,006,157	T/C	—	uncertain significance
rs41272110	6:161,006,172	T/C	missense variant	—
rs1330156289	6:161,007,503	G/T	—	uncertain significance
rs771704976	6:161,007,529	T/C	—	uncertain significance
rs778923400	6:161,007,584	T/A	—	uncertain significance
rs201628383	6:161,007,618	C/T	—	uncertain significance
rs147936725	6:161,007,619	G/T	—	benign
rs2115039719	6:161,007,628	C/T	—	uncertain significance
rs532800913	6:161,007,759	C/G	—	—
rs568254317	6:161,009,118	T/C	—	—
rs187631026	6:161,009,556	A/G	intron variant	—
rs755615196	6:161,009,928	G/T	—	—

Showing 100 of 212 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.