rs514230

This variant is located in the LINC01132 gene.

▶

GWAS Catalog Trait Associations (35)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

total cholesterol measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele A

OR 0.05

p 5.0e-84

N 355,858

Major Consortium StudyLarge GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.03

p 4.0e-41

N 397,478

Major Consortium StudyLarge GWAS

European

Teslovich TM et al. “Biological, clinical and population relevance of 95 loci for blood lipids.” Nature 466(7307):707-713 (2010)

Allele A

OR 1.36

p 5.0e-14

N 100,184

Large GWAS

European

Hoffmann TJ et al. “A large electronic-health-record-based genome-wide study of serum lipids.” Nature Genetics 50(3):401-413 (2018)

Allele A

OR —

β 0.038

p 2.0e-16

N 94,674

Large GWAS

multi-ancestry

Willer CJ et al. “Discovery and refinement of loci associated with lipid levels.” Nature Genetics 45(11):1274-1283 (2013)

Allele A

OR —

β 0.039

p 5.0e-14

N 94,595

Large GWAS

European

Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)

Allele A

OR 0.03

p 9.0e-12

N 88,329

Large GWAS

European

low density lipoprotein cholesterol measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele A

OR 0.04

p 1.0e-74

N 355,197

Major Consortium StudyLarge GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.02

p 4.0e-22

N 404,687

Major Consortium StudyLarge GWAS

European

Bentley AR et al. “Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.” Nature Genetics 51(4):636-648 (2019)

Allele A

OR 1.14

p 9.0e-10

N 125,692

Large GWAS

multi-ancestry

Teslovich TM et al. “Biological, clinical and population relevance of 95 loci for blood lipids.” Nature 466(7307):707-713 (2010)

Allele A

OR 1.13

p 9.0e-12

N 95,454

Large GWAS

European

Hoffmann TJ et al. “A large electronic-health-record-based genome-wide study of serum lipids.” Nature Genetics 50(3):401-413 (2018)

Allele A

OR —

β 0.034

p 9.0e-13

N 94,674

Large GWAS

multi-ancestry

Willer CJ et al. “Discovery and refinement of loci associated with lipid levels.” Nature Genetics 45(11):1274-1283 (2013)

Allele A

OR —

β 0.036

p 9.0e-12

N 94,595

Large GWAS

European

Allele A

OR 0.03

p 3.0e-11

N 88,329

Large GWAS

European

Surakka I et al. “The impact of low-frequency and rare variants on lipid levels.” Nature Genetics 47(6):589-97 (2015)

Allele A

OR 0.04

p 1.0e-11

N 62,166

Large GWAS

European

apolipoprotein B measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele T

OR 0.04

p 4.0e-68

N 354,097

Major Consortium StudyLarge GWAS

multi-ancestry

Hypercholesterolemia

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.05

p 2.0e-28

N 315,668

Major Consortium StudyLarge GWAS

European

IGF-1 measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele T

OR 0.02

p 3.0e-22

N 353,824

Major Consortium StudyLarge GWAS

multi-ancestry

apolipoprotein A 1 measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele T

OR 0.02

p 1.0e-19

N 323,833

Major Consortium StudyLarge GWAS

multi-ancestry

hyperlipidemia

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.05

p 2.0e-19

N 426,603

Major Consortium StudyLarge GWAS

European

metabolic disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.05

p 2.0e-19

N 426,570

Major Consortium StudyLarge GWAS

European

omega-6 polyunsaturated fatty acid measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele A

OR —

p 8.0e-19

N 128,922

Large GWAS

European

linoleic acid measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele A

OR —

p 7.0e-18

N 128,922

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs514230

GWAS Catalog Trait Associations (35)

total cholesterol measurement

low density lipoprotein cholesterol measurement

apolipoprotein B measurement

Hypercholesterolemia

IGF-1 measurement

apolipoprotein A 1 measurement

hyperlipidemia

metabolic disease

omega-6 polyunsaturated fatty acid measurement

linoleic acid measurement

Community Wiki

Comments