Trait
SNPs associated with Hypercholesterolemia
133 genetic variants across 48 genes have been associated with Hypercholesterolemia in published research. Key genes include ABCA1, ABCA5, ABCA6.
Associated variants133 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs12740374 | CELSR2 | GWAS association (p=9.9e-324) | Major Consortium Study |
| rs7412 | APOE | GWAS association (p=9.9e-324) | Major Consortium Study |
| rs12151108 | — | GWAS association (p=1.0e-320) | Major Consortium Study |
| rs138294113 | — | GWAS association (p=1.0e-266) | Major Consortium Study |
| rs1065853 | — | GWAS association (p=3.0e-210) | Major Consortium Study |
| rs563290 | — | GWAS association (p=8.0e-131) | Major Consortium Study |
| rs66614050 | — | GWAS association (p=2.0e-119) | Major Consortium Study |
| rs142130958 | — | GWAS association (p=8.0e-71) | Major Consortium Study |
| rs28362286 | PCSK9 | GWAS association (p=2.0e-66) | Major Consortium Study |
| rs4245791 | ABCG8 | GWAS association (p=8.0e-59) | Major Consortium Study |
| rs10889342 | DOCK7 | GWAS association (p=6.0e-46) | Major Consortium Study |
| rs2000999 | HPR | GWAS association (p=1.0e-45) | Major Consortium Study |
| rs143020224 | — | GWAS association (p=8.0e-44) | Major Consortium Study |
| rs11648003 | — | GWAS association (p=2.0e-31) | Major Consortium Study |
| rs17725246 | — | GWAS association (p=6.0e-29) | Major Consortium Study |
| rs514230 | LINC01132 | GWAS association (p=2.0e-28) | Major Consortium Study |
| rs6882076 | TIMD4 | GWAS association (p=4.0e-26) | Major Consortium Study |
| rs3208305 | LPL | GWAS association (p=9.0e-25) | Major Consortium Study |
| rs1331309 | — | GWAS association (p=3.0e-22) | Major Consortium Study |
| rs2043082 | — | GWAS association (p=3.0e-22) | Major Consortium Study |
| rs7188250 | — | GWAS association (p=5.0e-21) | Major Consortium Study |
| rs1495743 | — | GWAS association (p=2.0e-20) | Major Consortium Study |
| rs174549 | FADS1 | GWAS association (p=2.0e-20) | Major Consortium Study |
| rs556107 | — | GWAS association (p=4.0e-19) | Major Consortium Study |
| rs6689 | HLA-DQB1 | GWAS association (p=3.0e-17) | Major Consortium Study |
| rs73066485 | — | GWAS association (p=6.0e-17) | Major Consortium Study |
| rs35570672 | — | GWAS association (p=2.0e-16) | Major Consortium Study |
| rs9399137 | — | GWAS association (p=3.0e-16) | Major Consortium Study |
| rs78689694 | ST3GAL4 | GWAS association (p=3.0e-16) | Major Consortium Study |
| rs1584063 | — | GWAS association (p=5.0e-16) | Major Consortium Study |
| rs10195252 | — | GWAS association (p=2.0e-15) | Major Consortium Study |
| rs174544 | FADS1 | GWAS association (p=3.0e-15) | Major Consortium Study |
| rs79920061 | — | GWAS association (p=4.0e-15) | Major Consortium Study |
| rs2073547 | NPC1L1 | GWAS association (p=6.0e-15) | Major Consortium Study |
| rs12464355 | INSIG2 | GWAS association (p=1.0e-14) | Major Consortium Study |
| rs2575876 | ABCA1 | GWAS association (p=2.0e-14) | Major Consortium Study |
| rs6602912 | — | GWAS association (p=9.0e-14) | Major Consortium Study |
| rs60201663 | PMFBP1 | GWAS association (p=1.0e-13) | Major Consortium Study |
| rs9879870 | PXK | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs61946991 | N4BP2L1 | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs75460349 | — | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs7177289 | — | GWAS association (p=3.0e-13) | Major Consortium Study |
| rs62033406 | — | GWAS association (p=4.0e-13) | Major Consortium Study |
| rs11549407 | HBB | GWAS association (p=4.0e-13) | Major Consortium Study |
| rs1408 | — | GWAS association (p=4.0e-13) | Major Consortium Study |
| rs59950280 | — | GWAS association (p=5.0e-13) | Major Consortium Study |
| rs1712248 | — | GWAS association (p=6.0e-13) | Major Consortium Study |
| rs6982502 | — | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs4841132 | LOC157273 | GWAS association (p=2.0e-12) | Major Consortium Study |
| rs11785060 | PLEC | GWAS association (p=7.0e-12) | Major Consortium Study |
| rs1169288 | HNF1A | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs13283282 | — | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs9875338 | — | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs6905288 | POLR1C | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs1497406 | EPHA2-AS1 | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs28601761 | — | GWAS association (p=1.0e-209) | Major Consortium Study |
| rs4299376 | ABCG8 | GWAS association (p=2.0e-78) | Major Consortium Study |
| rs58542926 | TM6SF2 | GWAS association (p=1.0e-144) | Major Consortium Study |
| rs11591147 | PCSK9 | GWAS association (p=6.0e-184) | Major Consortium Study |
| rs1260326 | GCKR | GWAS association (p=2.0e-91) | Major Consortium Study |
| rs2618567 | — | GWAS association (p=1.0e-16) | Major Consortium Study |
| rs1883711 | — | GWAS association (p=1.0e-38) | Major Consortium Study |
| rs4860951 | — | GWAS association (p=2.0e-27) | Major Consortium Study |
| rs12916 | HMGCR | GWAS association (p=7.0e-70) | Major Consortium Study |
| rs10455872 | LPA | GWAS association (p=4.0e-117) | Major Consortium Study |
| rs9987289 | LOC157273 | GWAS association (p=7.0e-19) | Major Consortium Study |
| rs9297994 | — | GWAS association (p=1.0e-28) | Major Consortium Study |
| rs115478735 | ABO | GWAS association (p=5.0e-80) | Major Consortium Study |
| rs7903146 | TCF7L2 | GWAS association (p=6.0e-19) | Major Consortium Study |
| rs964184 | APOA5 | GWAS association (p=8.0e-152) | Major Consortium Study |
| rs10846744 | SCARB1 | GWAS association (p=1.0e-24) | Major Consortium Study |
| rs544187825 | — | GWAS association (p=4.0e-26) | Major Consortium Study |
| rs573431210 | ABCA5 | GWAS association (p=4.0e-22) | Major Consortium Study |
| rs4485425 | — | GWAS association (p=2.0e-16) | Major Consortium Study |
| rs668948 | LOC124905593 | GWAS association (p=7.0e-167) | Major Consortium Study |
| rs5471 | HP | GWAS association (p=1.0e-19) | Major Consortium Study |
| rs7528419 | CELSR2 | GWAS association (p=9.9e-324) | Major Consortium Study |
| rs17248727 | LDLR | GWAS association (p=7.0e-135) | Large GWAS |
| rs484195 | APOC1 | GWAS association (p=8.0e-67) | Large GWAS |
| rs74617384 | — | GWAS association (p=2.0e-58) | Large GWAS |
| rs3843480 | — | GWAS association (p=2.0e-47) | Large GWAS |
| rs140570886 | — | GWAS association (p=3.0e-42) | Large GWAS |
| rs1305520 | DOCK7 | GWAS association (p=7.0e-40) | Large GWAS |
| rs535713 | — | GWAS association (p=9.0e-40) | Large GWAS |
| rs13306206 | APOB | GWAS association (p=1.0e-38) | Large GWAS |
| rs576249617 | — | GWAS association (p=5.0e-32) | Large GWAS |
| rs117113213 | — | GWAS association (p=3.0e-30) | Large GWAS |
| rs72658867 | LDLR | GWAS association (p=8.0e-30) | Large GWAS |
| rs34042070 | — | GWAS association (p=4.0e-25) | Large GWAS |
| rs1363232 | — | GWAS association (p=7.0e-24) | Large GWAS |
| rs77542162 | ABCA6 | GWAS association (p=9.0e-24) | Large GWAS |
| rs1077835 | LIPC | GWAS association (p=1.0e-23) | Large GWAS |
| rs17244834 | HMGCR | GWAS association (p=2.0e-23) | Large GWAS |
| rs9295123 | — | GWAS association (p=6.0e-21) | Large GWAS |
| rs2495491 | — | GWAS association (p=8.0e-21) | Large GWAS |
| rs821840 | CETP | GWAS association (p=1.0e-20) | Large GWAS |
| rs15285 | LPL | GWAS association (p=1.0e-19) | Large GWAS |
| rs601338 | FUT2 | GWAS association (p=5.0e-19) | Large GWAS |
| rs374095935 | — | GWAS association (p=7.0e-19) | Large GWAS |
| rs45611741 | APOA5 | GWAS association (p=7.0e-19) | Large GWAS |
Showing the top 100 of 133 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.