HPR
haptoglobin-related protein
Summary
This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
Known Variants46 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs75444904 | 16:72,095,650 | A/C | downstream gene variant | — |
| rs145116658 | 16:72,097,786 | C/T | downstream gene variant | — |
| rs217184 | 16:72,105,965 | T/C | intron variant | — |
| rs2000999 | 16:72,108,093 | G/A | intron variant | — |
| rs201818109 | 16:72,108,188 | C/G | — | uncertain significance |
| rs200255876 | 16:72,108,192 | T/G | — | likely benign |
| rs773105549 | 16:72,108,195 | C/A | — | uncertain significance |
| rs759953433 | 16:72,108,200 | C/A | — | uncertain significance |
| rs765914803 | 16:72,108,206 | G/A | — | uncertain significance |
| rs201044200 | 16:72,108,210 | T/C | — | uncertain significance |
| rs184025907 | 16:72,108,234 | T/C | — | likely benign |
| rs187620078 | 16:72,108,236 | T/G | — | likely benign |
| rs367988509 | 16:72,108,239 | C/T | — | uncertain significance |
| rs152833 | 16:72,108,264 | G/C | — | uncertain significance |
| rs368767302 | 16:72,108,269 | C/T | — | uncertain significance |
| rs182745400 | 16:72,108,270 | G/A | — | uncertain significance |
| rs749735295 | 16:72,110,220 | A/G | — | uncertain significance |
| rs560060008 | 16:72,110,231 | C/G | — | likely benign |
| rs146254843 | 16:72,110,323 | G/T | — | benign |
| rs2507037908 | 16:72,110,376 | T/C | — | uncertain significance |
| rs2507037916 | 16:72,110,378 | A/C | — | uncertain significance |
| rs373853317 | 16:72,110,404 | A/T | — | uncertain significance |
| rs200632830 | 16:72,110,409 | T/C | — | uncertain significance |
| rs675973 | 16:72,110,467 | G/T | — | benign |
| rs2507038209 | 16:72,110,477 | C/G | — | uncertain significance |
| rs574707341 | 16:72,110,486 | C/T | — | uncertain significance |
| rs675948 | 16:72,110,487 | A/C | — | uncertain significance |
| rs566895231 | 16:72,110,561 | C/T | — | uncertain significance |
| rs201950483 | 16:72,110,594 | G/T | — | uncertain significance |
| rs765037046 | 16:72,110,609 | T/G | — | uncertain significance |
| rs147899609 | 16:72,110,637 | C/A | — | likely benign |
| rs760913553 | 16:72,110,681 | G/A | — | likely benign |
| rs201744401 | 16:72,110,703 | G/A | — | uncertain significance |
| rs1486481368 | 16:72,110,753 | C/T | — | uncertain significance |
| rs199986081 | 16:72,110,756 | A/G | — | uncertain significance |
| rs201688913 | 16:72,110,783 | G/A | — | uncertain significance |
| rs775848664 | 16:72,110,793 | A/C | — | uncertain significance |
| rs374535436 | 16:72,110,826 | G/A | — | uncertain significance |
| rs781564700 | 16:72,110,831 | G/A | — | uncertain significance |
| rs573772360 | 16:72,110,840 | G/A | — | likely benign |
| rs369925214 | 16:72,110,871 | C/T | — | uncertain significance |
| rs149194838 | 16:72,110,873 | G/A | — | uncertain significance |
| rs470710 | 16:72,110,882 | C/T | — | benign |
| rs1376797409 | 16:72,110,903 | G/T | — | uncertain significance |
| rs370432256 | 16:72,110,906 | G/A | — | uncertain significance |
| rs12646 | 16:72,110,948 | C/G | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.