rs138294113
This is a intergenic variant variant.
▶GWAS Catalog Trait Associations (13)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (13)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Hypercholesterolemia
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.28
p 1.0e-266
N 404,034
Major Consortium StudyLarge GWAS
multi-ancestry
low density lipoprotein cholesterol measurement
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele T
OR 0.24
p 7.0e-239
N 99,432
Large GWAS
African American or Afro-Caribbean, African unspecified
hyperlipidemia
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.24
p 3.0e-220
N 602,872
Major Consortium StudyLarge GWAS
multi-ancestry
total cholesterol measurement
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele T
OR 0.21
p 4.0e-186
N 99,432
Large GWAS
African American or Afro-Caribbean, African unspecified
non-high density lipoprotein cholesterol measurement
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele T
OR 0.23
p 2.0e-56
N 99,432
Large GWAS
African American or Afro-Caribbean, African unspecified
Hypercholesterolemia, family history
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.12
p 1.0e-29
N 404,034
Major Consortium StudyLarge GWAS
multi-ancestry
depressive symptom measurement, low density lipoprotein cholesterol measurement
Bentley AR et al. “Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.” Translational Psychiatry 15(1):207 (2025)
Allele T
OR —
β 1.383
p 7.0e-25
N 15,949
Large GWAS
Hispanic or Latin American
social deprivation, low density lipoprotein cholesterol measurement
Bentley AR et al. “Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.” Translational Psychiatry 15(1):207 (2025)
Allele T
OR —
β 0.889
p 3.0e-19
N 15,949
Large GWAS
Hispanic or Latin American
familial lipoprotein lipase deficiency
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.13
p 3.0e-17
N 620,120
Major Consortium StudyLarge GWAS
multi-ancestry
lipoprotein A measurement
Said MA et al. “Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein(a) Concentration: Protective Missense Variant on Lipoprotein(a) Concentration-Brief Report.” Arteriosclerosis, Thrombosis, and Vascular Biology 41(5):1792-1800 (2021)
Allele C
OR 0.02
p 3.0e-17
N 371,212
Large GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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