LIPC

lipase C, hepatic type

Summary

Enables phospholipase A1 activity and triacylglycerol lipase activity. Involved in several processes, including cholesterol homeostasis; plasma lipoprotein particle remodeling; and triglyceride catabolic process. Located in extracellular space. Implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Biomarker of hyperinsulinism; obesity; and type 1 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants274 total

rsidPosition (GRCh37)AllelesClassClinVar
rs19116976915:58,701,059T/Gupstream gene variant—
rs1724087615:58,701,551A/Gupstream gene variant—
rs14987705415:58,703,716C/Tintron variant—
rs15018935315:58,705,515T/Cintron variant—
rs7934100215:58,707,990C/Gintron variant—
rs18260766915:58,708,071T/Aintron variant—
rs6031539415:58,709,181C/Tintron variant—
rs11686942115:58,709,436T/Cintron variant—
rs55002841215:58,710,475T/C——
rs1185738015:58,712,203T/G5 prime UTR variant—
rs107783515:58,723,426A/Gdownstream gene variant—
rs107783415:58,723,479T/G——
rs3558860415:58,723,587G/C——
rs180058815:58,723,675C/Tdownstream gene variantassociation
rs207089515:58,723,939G/Aregulatory region variantrisk factor
rs75640286515:58,724,236A/T—uncertain significance
rs189314080815:58,724,243T/G—uncertain significance
rs189314196815:58,724,265T/G—uncertain significance
rs14539886115:58,724,298C/T—conflicting classifications of pathogenicity
rs78026776615:58,724,309C/G—uncertain significance
rs20121985815:58,724,324G/C—uncertain significance
rs13792622815:58,724,327C/A—conflicting classifications of pathogenicity
rs819270115:58,724,371C/T—benign
rs1163134215:58,724,383A/G—benign
rs649400515:58,724,524G/A—benign
rs803480215:58,724,792T/G——
rs1719051015:58,726,463G/Cdownstream gene variant—
rs26133415:58,726,744G/A——
rs26133215:58,727,325A/Gcoding sequence variant—
rs6200093915:58,727,687T/Gcoding sequence variant—
rs58813615:58,730,498C/G——
rs11132358415:58,730,594G/Aintron variant—
rs1730173915:58,730,639C/Gintron variant—
rs26134215:58,731,153G/A——
rs804331015:58,731,818C/T——
rs1259437515:58,732,468G/Aregulatory region variantassociation
rs5999992315:58,734,397G/Cregulatory region variant—
rs47322415:58,737,341T/Gintron variant—
rs19282817415:58,737,690G/Tintron variant—
rs802350315:58,740,588C/Tintron variantassociation
rs48567115:58,741,134A/T——
rs26133615:58,742,418G/Aintron variant—
rs382577615:58,746,830T/A——
rs18339480015:58,752,855G/T——
rs1259300815:58,760,975C/Aregulatory region variant—
rs54799017115:58,762,468G/C——
rs13861194315:58,789,534T/Cintron variant—
rs477506515:58,801,943A/C——
rs1290507615:58,805,243T/Cintron variant—
rs802875915:58,812,199C/Tupstream gene variant—
rs965247215:58,818,783G/Adownstream gene variant—
rs18458753315:58,830,528G/A—conflicting classifications of pathogenicity
rs76604385015:58,830,538T/G—uncertain significance
rs118479885415:58,830,550C/A—uncertain significance
rs15000938915:58,830,563A/G—likely benign
rs75599019315:58,830,575G/A—uncertain significance
rs127607019815:58,830,580A/G—uncertain significance
rs77755002315:58,830,585A/G—uncertain significance
rs14522329215:58,830,586T/G—uncertain significance
rs56817807615:58,830,608T/G—uncertain significance
rs76242100615:58,830,611A/G—likely benign
rs36926218115:58,830,636C/T—conflicting classifications of pathogenicity
rs14002972915:58,830,639A/G—uncertain significance
rs14355092515:58,830,649C/T—uncertain significance
rs20012742515:58,830,650G/A—conflicting classifications of pathogenicity
rs131377998215:58,830,652A/G—uncertain significance
rs11317425815:58,830,656G/A—likely benign
rs14636258515:58,830,668C/T—likely benign
rs77374225215:58,830,669G/T—uncertain significance
rs254877970715:58,830,695G/A—uncertain significance
rs141216563315:58,830,705C/T—uncertain significance
rs717541215:58,830,707C/T—likely benign
rs75708910715:58,830,715C/T—uncertain significance
rs14378628115:58,830,716G/A—uncertain significance
rs1163319115:58,830,966C/T—benign
rs7658842415:58,833,705T/C—benign
rs5969919015:58,833,742T/C—benign
rs607615:58,833,938G/A—benign
rs254878222015:58,833,979C/T—uncertain significance
rs77245630915:58,833,989C/T—likely benign
rs77578254315:58,833,990G/A—uncertain significance
rs607815:58,833,993G/A—uncertain significance
rs76526318315:58,834,018T/C—uncertain significance
rs76293855015:58,834,024C/T—uncertain significance
rs14101853015:58,834,026G/A—uncertain significance
rs18260375115:58,834,027C/T—uncertain significance
rs139132712115:58,834,028G/A—likely benign
rs56298829915:58,834,042C/T—uncertain significance
rs11349636515:58,834,043G/A—benign
rs75631142815:58,834,050C/A—uncertain significance
rs122414623915:58,834,059G/A—uncertain significance
rs189334041815:58,834,063G/A—uncertain significance
rs214091253215:58,834,084T/C—uncertain significance
rs76840984015:58,834,087C/A—uncertain significance
rs77611866115:58,834,091C/T—likely benign
rs26760427215:58,834,092G/T—uncertain significance
rs36782615715:58,834,106C/T—likely benign
rs77434670315:58,834,109C/A—likely benign
rs20101478915:58,834,113C/T—uncertain significance
rs37205478915:58,834,114G/A—uncertain significance

Showing 100 of 274 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.

LIPC — lipase C, hepatic type