rs1883711

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GWAS Catalog Trait Associations (161)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

low density lipoprotein cholesterol measurement

Klimentidis YC et al. “Phenotypic and Genetic Characterization of Lower LDL Cholesterol and Increased Type 2 Diabetes Risk in the UK Biobank.” Diabetes 69(10):2194-2205 (2020)

Allele G

OR 0.16

p 4.0e-171

N 431,167

Major Consortium StudyLarge GWAS

European

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele G

OR 0.13

p 2.0e-161

N 1,320,016

Large GWAS

European

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.06

p 3.0e-20

N 450,015

Large GWAS

multi-ancestry

Richardson TG et al. “Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.” Plos Medicine 17(3):e1003062 (2020)

Allele G

OR 0.10

p 1.0e-63

N 440,546

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.11

p 4.0e-55

N 416,487

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.10

p 8.0e-28

N 404,687

Major Consortium StudyLarge GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.10

p 3.0e-56

N 394,642

Large GWAS

European

Klarin D et al. “Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.” Nature Genetics 50(11):1514-1523 (2018)

Allele G

OR 0.11

p 9.0e-21

N 297,626

Major Consortium StudyLarge GWAS

multi-ancestry

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele G

OR 0.10

p 9.0e-16

N 115,082

Large GWAS

European

Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)

Allele G

OR 0.12

p 7.0e-17

N 88,329

Large GWAS

European

Surakka I et al. “The impact of low-frequency and rare variants on lipid levels.” Nature Genetics 47(6):589-97 (2015)

Allele G

OR 0.15

p 4.0e-16

N 62,166

Large GWAS

European

total cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele C

OR 0.12

p 1.0e-147

N 1,320,016

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.10

p 9.0e-50

N 480,086

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.13

p 1.0e-42

N 397,478

Major Consortium StudyLarge GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.09

p 6.0e-52

N 394,642

Large GWAS

European

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.10

p 4.0e-17

N 115,082

Large GWAS

European

Allele C

OR 0.09

p 2.0e-12

N 88,329

Large GWAS

European

Surakka I et al. “The impact of low-frequency and rare variants on lipid levels.” Nature Genetics 47(6):589-97 (2015)

Allele C

OR 0.15

p 2.0e-15

N 62,166

Large GWAS

European

non-high density lipoprotein cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele C

OR 0.14

p 5.0e-137

N 1,320,016

Large GWAS

European

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.06

p 7.0e-22

N 450,015

Large GWAS

multi-ancestry

apolipoprotein B measurement

Allele G

OR 0.09

p 3.0e-54

N 439,214

Large GWAS

European

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.06

p 6.0e-23

N 450,015

Large GWAS

multi-ancestry

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele G

OR 0.11

p 4.0e-18

N 115,082

Large GWAS

European

Allele G

OR 0.12

p 2.0e-18

N 88,329

Large GWAS

European

level of transthyretin in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.23

p 3.0e-53

N 47,745

Large GWAS

European

histidine measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.09

p 1.0e-51

N 450,015

Large GWAS

multi-ancestry

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.09

p 5.0e-13

N 114,897

Large GWAS

European

Allele C

OR 0.09

p 1.0e-11

N 88,197

Large GWAS

European

triglycerides in small HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.07

p 4.0e-38

N 450,015

Large GWAS

multi-ancestry

triglycerides in very small VLDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.07

p 4.0e-38

N 450,015

Large GWAS

multi-ancestry

Allele C

OR 0.10

p 5.0e-13

N 88,329

Large GWAS

European

triglycerides in IDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.07

p 6.0e-37

N 450,015

Large GWAS

multi-ancestry

Allele C

OR 0.10

p 4.0e-14

N 88,329

Large GWAS

European

triglycerides to total lipids in large HDL percentage

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.07

p 2.0e-36

N 450,015

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs1883711

GWAS Catalog Trait Associations (161)

low density lipoprotein cholesterol measurement

total cholesterol measurement

non-high density lipoprotein cholesterol measurement

apolipoprotein B measurement

level of transthyretin in blood

histidine measurement

triglycerides in small HDL measurement

triglycerides in very small VLDL measurement

triglycerides in IDL measurement

triglycerides to total lipids in large HDL percentage

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