Trait
SNPs associated with Metabolic Disease
92 genetic variants across 45 genes have been associated with Metabolic Disease in published research. Key genes include ABCA1, ABCG8, ABO.
Associated variants92 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs7528419 | CELSR2 | GWAS association (p=6.0e-294) | Major Consortium Study |
| rs73015020 | — | GWAS association (p=2.0e-197) | Major Consortium Study |
| rs28601761 | — | GWAS association (p=1.0e-175) | Major Consortium Study |
| rs11591147 | PCSK9 | GWAS association (p=2.0e-156) | Major Consortium Study |
| rs668948 | LOC124905593 | GWAS association (p=2.0e-143) | Major Consortium Study |
| rs112875651 | — | GWAS association (p=2.0e-110) | Major Consortium Study |
| rs28362286 | PCSK9 | GWAS association (p=8.0e-102) | Major Consortium Study |
| rs10455872 | LPA | GWAS association (p=1.0e-98) | Major Consortium Study |
| rs4299376 | ABCG8 | GWAS association (p=4.0e-75) | Major Consortium Study |
| rs115478735 | ABO | GWAS association (p=1.0e-65) | Major Consortium Study |
| rs1260326 | GCKR | GWAS association (p=5.0e-54) | Major Consortium Study |
| rs12239736 | — | GWAS association (p=4.0e-49) | Major Consortium Study |
| rs11207982 | DOCK7 | GWAS association (p=3.0e-48) | Major Consortium Study |
| rs15285 | LPL | GWAS association (p=8.0e-46) | Major Consortium Study |
| rs544187825 | — | GWAS association (p=3.0e-38) | Major Consortium Study |
| rs60201663 | PMFBP1 | GWAS association (p=1.0e-31) | Major Consortium Study |
| rs56156922 | — | GWAS association (p=1.0e-29) | Major Consortium Study |
| rs6882076 | TIMD4 | GWAS association (p=4.0e-29) | Major Consortium Study |
| rs1421085 | FTO | GWAS association (p=6.0e-29) | Major Consortium Study |
| rs1558902 | FTO | GWAS association (p=5.0e-24) | Major Consortium Study |
| rs7903146 | TCF7L2 | GWAS association (p=4.0e-23) | Major Consortium Study |
| rs2575876 | ABCA1 | GWAS association (p=8.0e-23) | Major Consortium Study |
| rs183130 | CETP | GWAS association (p=8.0e-23) | Major Consortium Study |
| rs10846742 | — | GWAS association (p=1.0e-22) | Major Consortium Study |
| rs17725246 | — | GWAS association (p=2.0e-22) | Major Consortium Study |
| rs2068888 | — | GWAS association (p=7.0e-22) | Major Consortium Study |
| rs1169288 | HNF1A | GWAS association (p=3.0e-21) | Major Consortium Study |
| rs6812826 | — | GWAS association (p=7.0e-21) | Major Consortium Study |
| rs6072336 | — | GWAS association (p=1.0e-20) | Major Consortium Study |
| rs3809770 | — | GWAS association (p=2.0e-19) | Major Consortium Study |
| rs514230 | LINC01132 | GWAS association (p=2.0e-19) | Major Consortium Study |
| rs10846744 | SCARB1 | GWAS association (p=2.0e-19) | Major Consortium Study |
| rs61194703 | — | GWAS association (p=3.0e-19) | Major Consortium Study |
| rs4245791 | ABCG8 | GWAS association (p=3.0e-19) | Major Consortium Study |
| rs2176040 | — | GWAS association (p=8.0e-19) | Major Consortium Study |
| rs6982502 | — | GWAS association (p=1.0e-17) | Major Consortium Study |
| rs998584 | POLR1C | GWAS association (p=2.0e-17) | Major Consortium Study |
| rs9389269 | LOC105378010 | GWAS association (p=3.0e-17) | Major Consortium Study |
| rs740516 | — | GWAS association (p=8.0e-17) | Major Consortium Study |
| rs1584063 | — | GWAS association (p=2.0e-16) | Major Consortium Study |
| rs12350739 | — | GWAS association (p=3.0e-16) | Major Consortium Study |
| rs12464355 | INSIG2 | GWAS association (p=2.0e-15) | Major Consortium Study |
| rs7216664 | UNC13D | GWAS association (p=2.0e-15) | Major Consortium Study |
| rs6689 | HLA-DQB1 | GWAS association (p=2.0e-15) | Major Consortium Study |
| rs10107182 | — | GWAS association (p=3.0e-15) | Major Consortium Study |
| rs59950280 | — | GWAS association (p=9.0e-15) | Major Consortium Study |
| rs1495743 | — | GWAS association (p=6.0e-14) | Major Consortium Study |
| rs10184004 | — | GWAS association (p=9.0e-14) | Major Consortium Study |
| rs3755636 | PCCB | GWAS association (p=9.0e-14) | Major Consortium Study |
| rs77375493 | JAK2 | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs10869462 | — | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs174544 | FADS1 | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs112771035 | — | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs115495897 | — | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs553430182 | LOC105371953 | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs10195252 | — | GWAS association (p=3.0e-13) | Major Consortium Study |
| rs8078994 | GIP | GWAS association (p=4.0e-13) | Major Consortium Study |
| rs35931 | ARL15 | GWAS association (p=5.0e-13) | Major Consortium Study |
| rs11445081 | — | GWAS association (p=6.0e-13) | Major Consortium Study |
| rs567449736 | STARD4-AS1 | GWAS association (p=7.0e-13) | Major Consortium Study |
| rs3936511 | — | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs4921913 | — | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs28817415 | SHROOM3 | GWAS association (p=3.0e-12) | Major Consortium Study |
| rs183995421 | LOC124906112 | GWAS association (p=3.0e-12) | Major Consortium Study |
| rs377126456 | EIF4G1 | GWAS association (p=4.0e-12) | Major Consortium Study |
| rs530034781 | GAREM1 | GWAS association (p=4.0e-12) | Major Consortium Study |
| rs35529421 | DOCK7 | GWAS association (p=5.0e-12) | Major Consortium Study |
| rs729781 | TBX2 | GWAS association (p=5.0e-12) | Major Consortium Study |
| rs157934 | — | GWAS association (p=8.0e-12) | Major Consortium Study |
| rs7215775 | TBX2 | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs523118 | — | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs144383384 | MAML2 | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs28394165 | SHROOM3 | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs72495043 | INSIG2 | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs4470903 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs138828608 | DGKG | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs112175198 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs17476364 | — | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs193159913 | BMPR2 | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs2618566 | — | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs74181299 | CEP68 | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs571758295 | — | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs193193439 | RBFOX1 | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs12740374 | CELSR2 | GWAS association (p=7.0e-262) | Major Consortium Study |
| rs58542926 | TM6SF2 | GWAS association (p=1.0e-118) | Major Consortium Study |
| rs7412 | APOE | GWAS association (p=9.9e-324) | Major Consortium Study |
| rs964184 | APOA5 | GWAS association (p=6.0e-193) | Major Consortium Study |
| rs12916 | HMGCR | GWAS association (p=3.0e-51) | Major Consortium Study |
| rs142130958 | — | GWAS association (p=6.0e-219) | Major Consortium Study |
| rs563290 | — | GWAS association (p=1.0e-131) | Major Consortium Study |
| rs2126264 | — | GWAS association (p=5.0e-15) | Major Consortium Study |
| rs149124714 | CARMIL1 | GWAS association (p=9.0e-20) | Large GWAS |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.