rs12350739
This is a regulatory region variant variant.
▶GWAS Catalog Trait Associations (14)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (14)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
blood protein amount
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.11
p 4.0e-109
N 47,745
Large GWAS
European
actinic keratosis
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.11
p 1.0e-95
N 412,119
Major Consortium StudyLarge GWAS
European
Kim Y et al. “Genome-wide association study of actinic keratosis identifies new susceptibility loci implicated in pigmentation and immune regulation pathways.” Communications Biology 5(1):386 (2022)
Allele G
OR 0.88
p 6.0e-26
N 92,240
Large GWAS
European
skin cancer
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.10
p 1.0e-69
N 431,198
Major Consortium StudyLarge GWAS
European
skin neoplasm
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.10
p 2.0e-65
N 429,041
Major Consortium StudyLarge GWAS
European
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.07
p 3.0e-13
N 670,929
Large GWAS
multi-ancestry
strand of hair color
Hysi PG et al. “Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability.” Nature Genetics 50(5):652-656 (2018)
Allele A
OR 0.04
p 2.0e-44
N 290,891
Meta-analysisLarge GWAS
European
aging rate
Roberts V et al. “Genome-Wide Association Study Identifies Genetic Associations with Perceived Age.” The Journal of Investigative Dermatology 140(12):2380-2385 (2020)
Allele G
OR 1.05
p 1.0e-30
N 423,992
Large GWAS
European
skin disease
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.07
p 8.0e-30
N 574,078
Major Consortium StudyLarge GWAS
multi-ancestry
skin pigmentation
Vollenbrock CE et al. “Genome-wide association study identifies novel loci associated with skin autofluorescence in individuals without diabetes.” Bmc Genomics 23(1):840 (2022)
Allele A
OR 0.01
p 3.0e-27
N 27,254
Large GWAS
European
squamous cell carcinoma
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.11
p 3.0e-26
N 438,891
Major Consortium StudyLarge GWAS
European
hyperlipidemia
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.04
p 1.0e-16
N 426,603
Major Consortium StudyLarge GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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