Trait
SNPs associated with Skin Pigmentation
158 genetic variants across 18 genes have been associated with Skin Pigmentation in published research. Key genes include ADAMTS12, AMACR, ANKRD11.
Associated variants158 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs1426654 | SLC24A5 | Lighter skin pigmentation | Meta-analysis |
| rs35395 | — | GWAS association (p=2.0e-24) | Meta-analysis |
| rs16891982 | SLC45A2 | Lighter skin | Meta-analysis |
| rs10160510 | — | GWAS association (p=3.0e-10) | Meta-analysis |
| rs1448484 | OCA2 | GWAS association (p=4.0e-10) | Meta-analysis |
| rs36194177 | — | GWAS association (p=5.0e-10) | Meta-analysis |
| rs2636060 | — | GWAS association (p=6.0e-10) | Meta-analysis |
| rs1667392 | HERC2 | GWAS association (p=5.0e-09) | Meta-analysis |
| rs10416746 | — | GWAS association (p=6.0e-09) | Meta-analysis |
| rs3098576 | — | GWAS association (p=9.0e-09) | Meta-analysis |
| rs112332856 | — | GWAS association (p=2.0e-08) | Meta-analysis |
| rs35096708 | — | GWAS association (p=5.0e-151) | Large GWAS |
| rs28117 | — | GWAS association (p=2.0e-66) | Large GWAS |
| rs8049897 | — | GWAS association (p=5.0e-63) | Large GWAS |
| rs150909008 | — | GWAS association (p=2.0e-52) | Large GWAS |
| rs1805008 | MC1R | GWAS association (p=6.0e-50) | Large GWAS |
| rs6059655 | RALY | GWAS association (p=1.0e-49) | Large GWAS |
| rs12203592 | IRF4 | GWAS association (p=3.0e-47) | Large GWAS |
| rs1126809 | TYR | GWAS association (p=1.0e-45) | Large GWAS |
| rs7403279 | HERC2 | GWAS association (p=3.0e-44) | Large GWAS |
| rs7380538 | — | GWAS association (p=5.0e-35) | Large GWAS |
| rs35407 | — | GWAS association (p=1.0e-34) | Large GWAS |
| rs2278007 | SLC45A2 | GWAS association (p=1.0e-33) | Large GWAS |
| rs117990130 | — | GWAS association (p=8.0e-30) | Large GWAS |
| rs35563099 | — | GWAS association (p=1.0e-29) | Large GWAS |
| rs121918166 | OCA2 | GWAS association (p=7.0e-28) | Large GWAS |
| rs12350739 | — | GWAS association (p=3.0e-27) | Large GWAS |
| rs2591723 | ADAMTS12 | GWAS association (p=2.0e-25) | Large GWAS |
| rs9292519 | — | GWAS association (p=2.0e-25) | Large GWAS |
| rs190295257 | SPIRE2 | GWAS association (p=5.0e-20) | Large GWAS |
| rs55637757 | — | GWAS association (p=6.0e-20) | Large GWAS |
| rs1805006 | MC1R | GWAS association (p=3.0e-19) | Large GWAS |
| rs10565330 | — | GWAS association (p=8.0e-19) | Large GWAS |
| rs2067350 | — | GWAS association (p=8.0e-18) | Large GWAS |
| rs1423300 | — | GWAS association (p=3.0e-16) | Large GWAS |
| rs1805007 | MC1R | GWAS association (p=4.0e-16) | Large GWAS |
| rs367554063 | — | GWAS association (p=3.0e-15) | Large GWAS |
| rs117204628 | — | GWAS association (p=3.0e-15) | Large GWAS |
| rs10054129 | — | GWAS association (p=4.0e-15) | Large GWAS |
| rs17110447 | — | GWAS association (p=4.0e-15) | Large GWAS |
| rs642742 | KITLG | A allele associated with lighter skin pigmentation | Large GWAS |
| rs57525174 | — | GWAS association (p=2.0e-14) | Large GWAS |
| rs62052172 | — | GWAS association (p=4.0e-14) | Large GWAS |
| rs35400 | — | GWAS association (p=1.0e-13) | Large GWAS |
| rs10122939 | — | GWAS association (p=2.0e-13) | Large GWAS |
| rs34153565 | — | GWAS association (p=1.0e-12) | Large GWAS |
| rs11442532 | — | GWAS association (p=2.0e-12) | Large GWAS |
| rs1805009 | MC1R | Decreased skin pigmentation | Large GWAS |
| rs79014396 | — | GWAS association (p=6.0e-12) | Large GWAS |
| rs150231163 | HERC2 | GWAS association (p=8.0e-12) | Large GWAS |
| rs142046335 | — | GWAS association (p=1.0e-11) | Large GWAS |
| rs147936809 | HERC2 | GWAS association (p=1.0e-11) | Large GWAS |
| rs201918952 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs560973795 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs1800407 | OCA2 | GWAS association (p=3.0e-11) | Large GWAS |
| rs117201485 | HERC2 | GWAS association (p=4.0e-11) | Large GWAS |
| rs885479 | MC1R | GWAS association (p=4.0e-11) | Large GWAS |
| rs150763518 | — | GWAS association (p=9.0e-11) | Large GWAS |
| rs1800414 | OCA2 | GWAS association (p=1.0e-10) | Large GWAS |
| rs56743903 | HERC2 | GWAS association (p=3.0e-10) | Large GWAS |
| rs149359 | — | GWAS association (p=4.0e-10) | Large GWAS |
| rs7721230 | AMACR | GWAS association (p=4.0e-10) | Large GWAS |
| rs6792049 | — | GWAS association (p=4.0e-10) | Large GWAS |
| rs1214023646 | — | GWAS association (p=6.0e-10) | Large GWAS |
| rs2961906 | ADAMTS12 | GWAS association (p=7.0e-10) | Large GWAS |
| rs111372186 | — | GWAS association (p=9.0e-10) | Large GWAS |
| rs2049865 | — | GWAS association (p=9.0e-10) | Large GWAS |
| rs1335589229 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs4644350 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs117219845 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs58836608 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs2187128 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs36089417 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs11547464 | MC1R | GWAS association (p=2.0e-09) | Large GWAS |
| rs1290177 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs55950592 | — | GWAS association (p=4.0e-09) | Large GWAS |
| rs535930 | — | GWAS association (p=4.0e-09) | Large GWAS |
| rs35805265 | — | GWAS association (p=4.0e-09) | Large GWAS |
| rs78211086 | — | GWAS association (p=5.0e-09) | Large GWAS |
| rs145326083 | ADAMTS12 | GWAS association (p=7.0e-09) | Large GWAS |
| rs7116973 | TYR | GWAS association (p=7.0e-09) | Large GWAS |
| rs752243327 | — | GWAS association (p=7.0e-09) | Large GWAS |
| rs397977468 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs745333093 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs79743671 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs568405296 | HYDIN | GWAS association (p=2.0e-08) | Large GWAS |
| rs12921177 | DPEP1 | GWAS association (p=3.0e-08) | Large GWAS |
| rs17652091 | — | GWAS association (p=3.0e-08) | Large GWAS |
| rs1042602 | TYR | GWAS association (p=4.0e-08) | Large GWAS |
| rs4248913 | — | GWAS association (p=4.0e-08) | Large GWAS |
| rs62211613 | NCOA6 | GWAS association (p=4.0e-08) | Large GWAS |
| rs1001949 | — | GWAS association (p=4.0e-08) | Large GWAS |
| rs11636232 | HERC2 | GWAS association (p=1.0e-59) | Large GWAS |
| rs11649196 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs11742467 | — | GWAS association (p=2.0e-32) | Large GWAS |
| rs1184030188 | — | GWAS association (p=5.0e-30) | Large GWAS |
| rs13177787 | — | GWAS association (p=7.0e-43) | Large GWAS |
| rs1491276502 | — | GWAS association (p=4.0e-28) | Large GWAS |
| rs16891958 | — | GWAS association (p=3.0e-11) | Large GWAS |
| rs1805005 | MC1R | GWAS association (p=1.0e-11) | Large GWAS |
Showing the top 100 of 158 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.