SPIRE2
spire type actin nucleation factor 2
Summary
Predicted to enable microtubule binding activity. Involved in establishment of meiotic spindle localization; formin-nucleated actin cable assembly; and positive regulation of double-strand break repair. Predicted to be located in cleavage furrow. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants85 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs34177108 | 16:89,893,375 | C/A | upstream gene variant | — |
| rs1329749564 | 16:89,894,978 | G/C | — | uncertain significance |
| rs2041348256 | 16:89,894,999 | C/A | — | uncertain significance |
| rs2376876 | 16:89,895,026 | C/G | — | uncertain significance |
| rs771902606 | 16:89,895,050 | A/T | — | uncertain significance |
| rs1189423392 | 16:89,895,071 | A/G | — | uncertain significance |
| rs758665349 | 16:89,895,085 | G/A | — | uncertain significance |
| rs768508839 | 16:89,895,145 | G/T | — | uncertain significance |
| rs7198386 | 16:89,897,896 | A/C | intron variant | — |
| rs544301146 | 16:89,898,018 | A/G | — | — |
| rs190295257 | 16:89,906,879 | G/C | intron variant | — |
| rs6500458 | 16:89,907,205 | A/C | — | — |
| rs764519296 | 16:89,911,733 | C/T | — | uncertain significance |
| rs148489395 | 16:89,911,747 | G/A | — | uncertain significance |
| rs9745545 | 16:89,912,457 | A/T | — | — |
| rs373894738 | 16:89,916,733 | G/A | — | uncertain significance |
| rs145621381 | 16:89,916,774 | G/C | — | uncertain significance |
| rs1291356436 | 16:89,916,790 | C/T | — | uncertain significance |
| rs769360402 | 16:89,916,791 | C/T | — | uncertain significance |
| rs770757999 | 16:89,916,825 | C/A | — | uncertain significance |
| rs767387936 | 16:89,916,836 | A/G | — | uncertain significance |
| rs1481820488 | 16:89,916,859 | G/A | — | uncertain significance |
| rs1367543600 | 16:89,916,869 | A/G | — | uncertain significance |
| rs952195752 | 16:89,916,871 | G/C | — | uncertain significance |
| rs540617670 | 16:89,916,883 | G/A | — | uncertain significance |
| rs772029647 | 16:89,916,895 | G/A | — | uncertain significance |
| rs1191380212 | 16:89,916,908 | C/A | — | uncertain significance |
| rs991291773 | 16:89,917,034 | G/A | — | uncertain significance |
| rs1390009220 | 16:89,917,048 | A/G | — | uncertain significance |
| rs1333835477 | 16:89,917,054 | C/T | — | uncertain significance |
| rs375815496 | 16:89,920,718 | G/A | — | uncertain significance |
| rs1286873531 | 16:89,920,764 | A/G | — | likely benign |
| rs577681836 | 16:89,920,908 | T/G | — | uncertain significance |
| rs1325540897 | 16:89,920,919 | C/G | — | uncertain significance |
| rs763864236 | 16:89,920,920 | G/C | — | uncertain significance |
| rs2544439608 | 16:89,920,937 | G/A | — | uncertain significance |
| rs2041669635 | 16:89,920,961 | C/G | — | uncertain significance |
| rs763864136 | 16:89,920,998 | C/T | — | uncertain significance |
| rs766501159 | 16:89,921,011 | G/C | — | uncertain significance |
| rs201203620 | 16:89,921,043 | A/G | — | uncertain significance |
| rs779726566 | 16:89,921,048 | C/T | — | uncertain significance |
| rs2544441044 | 16:89,922,008 | G/A | — | uncertain significance |
| rs145384952 | 16:89,922,029 | C/T | — | uncertain significance |
| rs372155150 | 16:89,922,030 | G/A | — | uncertain significance |
| rs201202825 | 16:89,922,071 | C/T | — | uncertain significance |
| rs1243269391 | 16:89,922,072 | G/A | — | uncertain significance |
| rs752271250 | 16:89,922,078 | G/A | — | uncertain significance |
| rs185450073 | 16:89,922,505 | C/T | intron variant | — |
| rs543352266 | 16:89,922,552 | C/T | — | uncertain significance |
| rs762516892 | 16:89,922,561 | G/T | — | uncertain significance |
| rs2041689985 | 16:89,922,594 | A/T | — | uncertain significance |
| rs2544442124 | 16:89,922,609 | T/C | — | uncertain significance |
| rs780381068 | 16:89,922,615 | C/T | — | uncertain significance |
| rs762472678 | 16:89,922,620 | C/T | — | uncertain significance |
| rs747885807 | 16:89,924,860 | G/A | — | uncertain significance |
| rs1008885464 | 16:89,924,862 | G/C | — | uncertain significance |
| rs1567676834 | 16:89,924,902 | T/G | — | uncertain significance |
| rs138861470 | 16:89,925,586 | C/T | — | uncertain significance |
| rs370409614 | 16:89,925,609 | C/T | — | uncertain significance |
| rs575860963 | 16:89,925,615 | C/T | — | uncertain significance |
| rs745855438 | 16:89,925,622 | T/C | — | uncertain significance |
| rs758357045 | 16:89,925,635 | C/A | — | uncertain significance |
| rs748394611 | 16:89,925,666 | G/C | — | uncertain significance |
| rs368322186 | 16:89,925,700 | C/T | — | uncertain significance |
| rs558699748 | 16:89,925,718 | G/A | — | uncertain significance |
| rs764907088 | 16:89,925,742 | G/A | — | uncertain significance |
| rs754904770 | 16:89,925,754 | G/A | — | likely benign |
| rs781136100 | 16:89,925,756 | G/C | — | uncertain significance |
| rs370058356 | 16:89,927,093 | A/G | — | uncertain significance |
| rs143936823 | 16:89,927,101 | C/T | — | likely benign |
| rs28478911 | 16:89,927,102 | G/A | — | uncertain significance |
| rs2544447281 | 16:89,927,107 | T/A | — | uncertain significance |
| rs142258282 | 16:89,929,944 | C/T | — | uncertain significance |
| rs146263316 | 16:89,930,239 | C/T | — | uncertain significance |
| rs72813426 | 16:89,933,007 | A/T | — | — |
| rs530541658 | 16:89,934,601 | G/A | — | uncertain significance |
| rs117721733 | 16:89,935,984 | C/G | — | uncertain significance |
| rs201149997 | 16:89,936,043 | G/T | — | uncertain significance |
| rs137969169 | 16:89,936,062 | G/A | — | likely benign |
| rs760594646 | 16:89,936,486 | G/A | — | uncertain significance |
| rs148201713 | 16:89,936,525 | G/A | — | uncertain significance |
| rs146404751 | 16:89,936,577 | G/A | — | uncertain significance |
| rs199989171 | 16:89,936,613 | C/T | — | uncertain significance |
| rs574309721 | 16:89,936,619 | G/T | — | uncertain significance |
| rs756031641 | 16:89,936,664 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.