rs9745545
This variant is located in the SPIRE2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
neuroblastoma, cutaneous melanoma
Avitabile M et al. “Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibility locus that shows a long-range interaction with the SLC16A1 gene.” Carcinogenesis 41(3):284-295 (2020)
Allele C
OR 1.13
p 1.0e-12
N 42,380
Large GWAS
European
About SPIRE2
Predicted to enable microtubule binding activity. Involved in establishment of meiotic spindle localization; formin-nucleated actin cable assembly; and positive regulation of double-strand break repair. Predicted to be located in cleavage furrow. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all SPIRE2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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