rs35407

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

keratinocyte carcinoma

Liyanage UE et al. “Combined analysis of keratinocyte cancers identifies novel genome-wide loci.” Human Molecular Genetics 28(18):3148-3160 (2019)
Allele G
OR 1.65
p 5.0e-45
N 358,840
Large GWAS
European

skin pigmentation

Vollenbrock CE et al. “Genome-wide association study identifies novel loci associated with skin autofluorescence in individuals without diabetes.” Bmc Genomics 23(1):840 (2022)
Allele A
OR 0.02
p 1.0e-34
N 27,254
Large GWAS
European

cutaneous squamous cell carcinoma

Sarin KY et al. “Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma.” Nature Communications 11(1):820 (2020)
Allele A
OR 0.47
p 6.0e-31
N 699,198
Meta-analysisLarge GWAS
European
Chahal HS et al. “Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma.” Nature Communications 7:12048 (2016)
Allele A
OR 1.69
p 1.0e-13
N 287,137
Large GWAS
European

basal cell carcinoma

Chahal HS et al. “Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma.” Nature Communications 7:12510 (2016)
Allele G
OR 1.59
p 5.0e-27
N 275,209
Large GWAS
European

melanoma

Rashkin SR et al. “Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.” Nature Communications 11(1):4423 (2020)
Allele G
OR 2.08
p 2.0e-19
N 417,127
Large GWAS
European
Ransohoff KJ et al. “Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.” Oncotarget 8(11):17586-17592 (2017)
Allele G
OR 2.08
p 3.0e-19
N 291,407
Large GWAS
European

squamous cell carcinoma

Liyanage UE et al. “Combined analysis of keratinocyte cancers identifies novel genome-wide loci.” Human Molecular Genetics 28(18):3148-3160 (2019)
Allele G
OR 1.72
p 5.0e-19
N 635,331
Large GWAS
European

cancer

Rashkin SR et al. “Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.” Nature Communications 11(1):4423 (2020)
Allele A
OR —
p 3.0e-16
N 475,312
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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