NCOA6

nuclear receptor coactivator 6

Summary

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

Known Variants120 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs774423261	20:33,303,150	T/C	—	likely benign
rs747116291	20:33,315,167	C/T	—	uncertain significance
rs1162524099	20:33,315,191	A/G	—	uncertain significance
rs745781089	20:33,315,194	A/C	—	uncertain significance
rs376562008	20:33,320,380	G/C	—	likely benign
rs2075970515	20:33,324,520	G/A	—	uncertain significance
rs753335835	20:33,324,559	G/A	—	uncertain significance
rs113921126	20:33,326,680	T/C	intron variant	—
rs1419070038	20:33,328,223	G/A	—	uncertain significance
rs201674304	20:33,328,253	T/A	—	uncertain significance
rs778296686	20:33,328,268	G/A	—	uncertain significance
rs142121277	20:33,328,275	C/T	—	likely benign
rs775364207	20:33,328,279	G/T	—	likely benign
rs1330629197	20:33,328,293	G/T	—	uncertain significance
rs747486995	20:33,328,317	G/A	—	uncertain significance
rs146290271	20:33,328,322	C/A	—	uncertain significance
rs754575825	20:33,328,373	G/A	—	uncertain significance
rs61751051	20:33,328,420	C/T	—	benign
rs772189901	20:33,328,495	T/C	—	benign
rs1045342048	20:33,328,631	G/A	—	uncertain significance
rs758456559	20:33,328,641	G/A	—	conflicting classifications of pathogenicity
rs777861502	20:33,328,646	C/T	—	uncertain significance
rs755991725	20:33,328,797	G/C	—	uncertain significance
rs747726440	20:33,328,830	G/A	—	uncertain significance
rs759987385	20:33,328,857	T/C	—	uncertain significance
rs2516901690	20:33,328,895	G/A	—	uncertain significance
rs912810067	20:33,328,899	T/C	—	uncertain significance
rs1237065165	20:33,328,965	G/A	—	uncertain significance
rs987893481	20:33,329,137	A/G	—	likely benign
rs2516915841	20:33,329,244	T/C	—	uncertain significance
rs748647591	20:33,329,349	C/G	—	uncertain significance
rs769842433	20:33,329,406	T/C	—	uncertain significance
rs201823165	20:33,329,433	G/T	—	uncertain significance
rs767144610	20:33,329,446	A/G	—	likely benign
rs2516922957	20:33,329,450	A/G	—	likely benign
rs201957178	20:33,329,510	G/A	—	uncertain significance
rs376623830	20:33,329,673	G/T	—	uncertain significance
rs1002095349	20:33,329,700	G/A	—	uncertain significance
rs777841708	20:33,329,763	T/A	—	uncertain significance
rs2516935026	20:33,329,781	A/T	—	uncertain significance
rs779627811	20:33,330,039	T/C	—	uncertain significance
rs903211007	20:33,330,075	T/A	—	uncertain significance
rs1371178375	20:33,330,099	T/C	—	uncertain significance
rs1427506978	20:33,330,188	G/C	—	uncertain significance
rs748338976	20:33,330,443	G/A	—	uncertain significance
rs201362806	20:33,330,481	G/A	—	benign
rs61730987	20:33,330,548	G/A	—	conflicting classifications of pathogenicity
rs775318531	20:33,330,576	T/C	—	uncertain significance
rs147162504	20:33,330,675	T/C	—	uncertain significance
rs199598622	20:33,330,688	C/T	—	benign
rs140114422	20:33,330,692	C/G	—	uncertain significance
rs61752052	20:33,330,880	G/A	—	likely benign
rs567137771	20:33,330,894	G/A	—	uncertain significance
rs377722434	20:33,330,912	C/T	—	uncertain significance
rs760827509	20:33,330,966	G/T	—	uncertain significance
rs780676014	20:33,331,047	G/A	—	uncertain significance
rs556666321	20:33,331,073	G/A	—	uncertain significance
rs75656457	20:33,331,075	T/G	—	benign
rs141055034	20:33,334,619	C/T	—	uncertain significance
rs368044857	20:33,334,700	T/G	—	uncertain significance
rs371905070	20:33,334,718	C/T	—	uncertain significance
rs372333834	20:33,337,268	G/C	—	uncertain significance
rs2517115817	20:33,337,281	T/C	—	uncertain significance
rs1356016884	20:33,337,473	G/A	—	uncertain significance
rs61754975	20:33,337,506	G/T	—	uncertain significance
rs1420550118	20:33,337,551	T/A	—	uncertain significance
rs781133206	20:33,337,609	T/C	—	uncertain significance
rs1441523504	20:33,337,611	T/G	—	uncertain significance
rs2517143873	20:33,337,701	A/G	—	uncertain significance
rs148627295	20:33,337,702	T/C	—	uncertain significance
rs3787220	20:33,337,751	T/C	—	benign
rs561915690	20:33,337,785	G/A	—	uncertain significance
rs764406737	20:33,337,789	T/C	—	uncertain significance
rs146535550	20:33,337,794	T/A	—	uncertain significance
rs767719395	20:33,337,799	C/G	—	uncertain significance
rs200020067	20:33,337,827	T/C	—	uncertain significance
rs1161201199	20:33,337,842	T/C	—	uncertain significance
rs141301245	20:33,337,920	G/A	—	uncertain significance
rs2517157162	20:33,337,953	T/G	—	uncertain significance
rs199708954	20:33,338,001	G/A	—	uncertain significance
rs2517163927	20:33,338,064	T/C	—	uncertain significance
rs2076431709	20:33,338,097	T/A	—	uncertain significance
rs61736332	20:33,338,114	A/G	—	benign
rs370768185	20:33,338,271	G/A	—	uncertain significance
rs780397750	20:33,338,308	C/T	—	uncertain significance
rs778998644	20:33,342,612	G/T	—	uncertain significance
rs144477396	20:33,342,623	G/A	—	uncertain significance
rs148359628	20:33,342,629	G/C	—	uncertain significance
rs1312604626	20:33,342,639	C/A	—	uncertain significance
rs371988001	20:33,342,645	A/G	—	uncertain significance
rs753744643	20:33,345,238	C/T	—	likely benign
rs145751574	20:33,345,438	G/T	—	uncertain significance
rs536923349	20:33,345,494	T/C	—	uncertain significance
rs751187935	20:33,345,500	C/T	—	uncertain significance
rs747180026	20:33,345,555	C/A	—	uncertain significance
rs1265251124	20:33,345,637	T/C	—	uncertain significance
rs41290900	20:33,345,747	T/C	—	likely benign
rs774202183	20:33,345,751	T/C	—	uncertain significance
rs371936845	20:33,345,824	T/C	—	uncertain significance
rs757635641	20:33,345,829	T/C	—	uncertain significance

Showing 100 of 120 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.