DPEP1
dipeptidase 1
Summary
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]
Known Variants38 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7191697 | 16:89,678,165 | G/A | upstream gene variant | — |
| rs16965867 | 16:89,680,868 | C/T | intron variant | — |
| rs28592184 | 16:89,681,640 | G/A | intron variant | — |
| rs9673342 | 16:89,686,247 | T/A | — | — |
| rs3764254 | 16:89,686,691 | G/A | — | — |
| rs62068711 | 16:89,687,377 | G/A | intron variant | — |
| rs2280371 | 16:89,687,703 | G/A | intron variant | — |
| rs2434860 | 16:89,696,217 | C/T | — | — |
| rs374569343 | 16:89,696,829 | G/C | — | uncertain significance |
| rs2460451 | 16:89,697,792 | C/A | regulatory region variant | — |
| rs2250598 | 16:89,698,070 | C/A | — | — |
| rs420332 | 16:89,698,752 | C/T | intron variant | — |
| rs4785581 | 16:89,699,664 | C/A | regulatory region variant | — |
| rs2460449 | 16:89,700,747 | G/C | — | — |
| rs752018188 | 16:89,702,375 | G/C | — | uncertain significance |
| rs771323473 | 16:89,702,431 | G/A | — | uncertain significance |
| rs751213489 | 16:89,702,690 | C/T | — | uncertain significance |
| rs143918895 | 16:89,702,756 | A/C | — | uncertain significance |
| rs750576563 | 16:89,702,763 | G/A | — | likely benign |
| rs77417030 | 16:89,703,033 | G/A | — | uncertain significance |
| rs78315344 | 16:89,703,034 | C/A | — | uncertain significance |
| rs376403325 | 16:89,703,633 | C/T | — | uncertain significance |
| rs760575879 | 16:89,703,724 | A/G | — | uncertain significance |
| rs375079646 | 16:89,704,073 | C/T | — | uncertain significance |
| rs762541462 | 16:89,704,263 | G/T | — | uncertain significance |
| rs199564877 | 16:89,704,290 | G/A | — | uncertain significance |
| rs373692597 | 16:89,704,315 | C/T | — | uncertain significance |
| rs2544182311 | 16:89,704,344 | G/T | — | uncertain significance |
| rs536921565 | 16:89,704,507 | C/A | — | uncertain significance |
| rs527397911 | 16:89,704,568 | C/T | — | uncertain significance |
| rs1314500628 | 16:89,704,623 | T/A | — | uncertain significance |
| rs150576976 | 16:89,706,243 | G/A | downstream gene variant | — |
| rs2139455 | 16:89,707,099 | G/T | downstream gene variant | — |
| rs164751 | 16:89,707,636 | G/C | — | — |
| rs154656 | 16:89,708,003 | T/A | regulatory region variant | — |
| rs12921177 | 16:89,708,037 | G/A | regulatory region variant | — |
| rs154657 | 16:89,708,096 | G/A | downstream gene variant | — |
| rs164748 | 16:89,708,292 | C/A | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.