rs2434860

This variant is located in the DPEP1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

urinary metabolite measurement

Sadler MC et al. “Genetic determinants of zinc homeostasis and its role in cardiometabolic diseases.” Plos Genetics 21(12):e1011928 (2025)

Allele T

OR —

β 0.068

p 4.0e-11

N 10,103

Large GWAS

European

About DPEP1

The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]

View all DPEP1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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