GIP
gastric inhibitory polypeptide
Summary
This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]
Known Variants17 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs143829372 | 17:47,038,252 | G/C | — | uncertain significance |
| rs1567796499 | 17:47,039,118 | C/A | — | uncertain significance |
| rs2291725 | 17:47,039,132 | T/G | missense variant | — |
| rs2291726 | 17:47,039,254 | T/C | regulatory region variant | — |
| rs4794005 | 17:47,041,247 | G/A | intron variant | — |
| rs761410381 | 17:47,041,685 | C/G | — | uncertain significance |
| rs1376433031 | 17:47,041,699 | A/G | — | uncertain significance |
| rs769719679 | 17:47,041,754 | T/A | — | uncertain significance |
| rs760192622 | 17:47,041,781 | G/C | — | uncertain significance |
| rs4794006 | 17:47,042,117 | G/A | intron variant | — |
| rs9747749 | 17:47,042,496 | G/T | — | — |
| rs8078994 | 17:47,042,651 | A/G | intron variant | — |
| rs8079149 | 17:47,042,751 | A/G | intron variant | — |
| rs1224385086 | 17:47,044,572 | G/A | — | uncertain significance |
| rs937301 | 17:47,046,276 | A/C | — | — |
| rs3848460 | 17:47,047,114 | A/G | upstream gene variant | — |
| rs3895874 | 17:47,047,868 | G/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.