rs74181299
This is a regulatory region variant variant in the CEP68 gene.
▶GWAS Catalog Trait Associations (14)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (14)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
type 2 diabetes mellitus
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.05
p 4.0e-28
N 432,648
Major Consortium StudyLarge GWAS
European
diabetes mellitus
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.05
p 1.0e-27
N 431,305
Major Consortium StudyLarge GWAS
European
systolic blood pressure
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.03
p 3.0e-26
N 425,750
Major Consortium StudyLarge GWAS
European
pulse pressure measurement
Giri A et al. “Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.” Nature Genetics 51(1):51-62 (2019)
Allele C
OR 0.23
p 6.0e-20
N 459,777
Large GWAS
multi-ancestry
Warren HR et al. “Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.” Nature Genetics 49(3):403-415 (2017)
Allele C
OR 0.23
p 1.0e-12
N 140,886
Large GWAS
European
essential hypertension
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.05
p 8.0e-18
N 427,704
Major Consortium StudyLarge GWAS
European
hypertension
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.05
p 1.0e-17
N 428,138
Major Consortium StudyLarge GWAS
European
triglyceride measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.02
p 2.0e-17
N 558,012
Major Consortium StudyLarge GWAS
multi-ancestry
diabetes mellitus, Drugs used in diabetes use measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.05
p 1.0e-14
N 315,668
Major Consortium StudyLarge GWAS
European
atrial flutter
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.07
p 9.0e-14
N 620,415
Major Consortium StudyLarge GWAS
multi-ancestry
cardiac arrhythmia
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.03
p 2.0e-13
N 394,665
Major Consortium StudyLarge GWAS
European
About CEP68
Enables protein domain specific binding activity and protein kinase binding activity. Involved in centriole-centriole cohesion and protein localization to organelle. Located in several cellular components, including cytosol; microtubule organizing center; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
View all CEP68 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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