rs9389269

This is a upstream gene variant variant in the LOC105378010 gene.

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GWAS Catalog Trait Associations (12)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hemoglobin measurement

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)
Allele C
OR 0.21
p 9.0e-154
N 38,200
Large GWAS
European

erythrocyte attribute

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)
Allele C
OR 0.16
p 4.0e-95
N 38,277
Large GWAS
European

erythrocyte count

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.13
p 7.0e-74
N 55,750
Major Consortium StudyLarge GWAS
Hispanic or Latin American

platelet count

Yang Z et al. “Genetic basis of pregnancy-associated decreased platelet counts and gestational thrombocytopenia.” Blood 143(15):1528-1538 (2024)
Allele C
OR 0.13
p 6.0e-41
N 72,816
Large GWAS
East Asian

deficiency anemia

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.29
p 7.0e-32
N 624,264
Major Consortium StudyLarge GWAS
multi-ancestry

hyperlipidemia

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.05
p 2.0e-17
N 426,603
Major Consortium StudyLarge GWAS
European

metabolic disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.05
p 3.0e-17
N 426,570
Major Consortium StudyLarge GWAS
European

soluble transferrin receptor measurement

Allara E et al. “Novel loci and biomedical consequences of iron homoeostasis variation.” Communications Biology 7(1):1631 (2024)
Allele T
OR 0.06
p 3.0e-15
N 45,330
Large GWAS
European

guanine nucleotide exchange factor VAV3 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.05
p 1.0e-11
N 47,745
Large GWAS
European

ATP measurement

Nemkov T et al. “Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes.” Cell Metabolism 36(9):1979-1997.e13 (2024)
Allele C
OR 0.07
p 7.0e-10
N 11,334
Large GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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