rs141622900

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GWAS Catalog Trait Associations (35)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

apolipoprotein B measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele A
OR 0.71
p —
N 354,097
Major Consortium StudyLarge GWAS
multi-ancestry

low density lipoprotein cholesterol measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele A
OR 0.56
p —
N 355,197
Major Consortium StudyLarge GWAS
multi-ancestry
Petty LE et al. “Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.” Nature Communications 16(1):3438 (2025)
Allele A
OR 0.36
p 6.0e-146
N 60,405
Large GWAS
Hispanic or Latin American

total cholesterol measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele A
OR 0.43
p —
N 355,858
Major Consortium StudyLarge GWAS
multi-ancestry

triglyceride measurement

Kamiza AB et al. “Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.” Nature Communications 14(1):5403 (2023)
Allele A
OR 0.15
p 2.0e-249
N 125,000
Large GWAS
African American or Afro-Caribbean, Sub-Saharan African, African unspecified
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele A
OR 0.13
p 3.0e-124
N 355,577
Major Consortium StudyLarge GWAS
multi-ancestry
Harshfield EL et al. “Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.” Bmc Medicine 19(1):232 (2021)
Allele A
OR 0.21
p 5.0e-11
N 13,814
Large GWAS
European

apolipoprotein A 1 measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele A
OR 0.12
p 4.0e-87
N 323,833
Major Consortium StudyLarge GWAS
multi-ancestry

lipoprotein A measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele A
OR 0.11
p 5.0e-69
N 284,044
Major Consortium StudyLarge GWAS
multi-ancestry

C-reactive protein measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele A
OR 0.09
p 9.0e-61
N 355,127
Major Consortium StudyLarge GWAS
multi-ancestry

high density lipoprotein cholesterol measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele A
OR 0.07
p 3.0e-36
N 325,634
Major Consortium StudyLarge GWAS
multi-ancestry
Huang S et al. “The Born in Guangzhou Cohort Study enables generational genetic discoveries.” Nature 626(7999):565-573 (2024)
Allele A
OR 0.42
p 3.0e-10
N 1,532
Large GWAS
East Asian

Alzheimer disease

Willett JDS et al. “Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(2):e14592 (2025)
Allele A
OR —
p 5.0e-25
N 27,907
Large GWAS
European, African unspecified, Hispanic or Latin American, Asian unspecified, NR

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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