Trait
SNPs associated with Alzheimer disease
472 genetic variants across 91 genes have been associated with Alzheimer disease in published research. Key genes include ABCA1, ABCA7, ABI3.
Associated variants472 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs2075650 | TOMM40 | GWAS association (p=1.0e-295) | Meta-analysis |
| rs41289512 | — | GWAS association (p=3.0e-194) | Meta-analysis |
| rs157580 | TOMM40 | GWAS association (p=9.0e-186) | Meta-analysis |
| rs6733839 | LOC105373605 | GWAS association (p=6.0e-118) | Meta-analysis |
| rs7412 | APOE | GWAS association (p=4.0e-106) | Meta-analysis |
| rs5167 | — | GWAS association (p=4.0e-51) | Meta-analysis |
| rs679515 | CR1 | GWAS association (p=7.0e-46) | Meta-analysis |
| rs1582763 | — | GWAS association (p=4.0e-42) | Meta-analysis |
| rs10792832 | — | GWAS association (p=2.0e-40) | Meta-analysis |
| rs4663105 | — | GWAS association (p=3.0e-39) | Meta-analysis |
| rs12151021 | — | GWAS association (p=2.0e-37) | Meta-analysis |
| rs1532276 | — | GWAS association (p=2.0e-37) | Meta-analysis |
| rs75932628 | TREM2 | GWAS association (p=3.0e-37) | Meta-analysis |
| rs7384878 | — | GWAS association (p=1.0e-26) | Meta-analysis |
| rs7232 | MS4A6A | GWAS association (p=2.0e-26) | Meta-analysis |
| rs117618017 | — | GWAS association (p=2.0e-25) | Meta-analysis |
| rs9331896 | CLU | GWAS association (p=3.0e-25) | Meta-analysis |
| rs6656401 | CR1 | GWAS association (p=6.0e-24) | Meta-analysis |
| rs73223431 | PTK2B | GWAS association (p=4.0e-22) | Meta-analysis |
| rs11218343 | SORL1 | GWAS association (p=1.0e-21) | Meta-analysis |
| rs12590654 | — | GWAS association (p=4.0e-21) | Meta-analysis |
| rs6014724 | — | GWAS association (p=4.0e-21) | Meta-analysis |
| rs5848 | GRN | GWAS association (p=2.0e-20) | Meta-analysis |
| rs4236673 | CLU | GWAS association (p=6.0e-20) | Meta-analysis |
| rs6605556 | — | GWAS association (p=7.0e-20) | Meta-analysis |
| rs117807585 | — | GWAS association (p=3.0e-19) | Meta-analysis |
| rs7912495 | — | GWAS association (p=1.0e-18) | Meta-analysis |
| rs10933431 | — | GWAS association (p=1.0e-18) | Meta-analysis |
| rs113706587 | — | GWAS association (p=2.0e-16) | Meta-analysis |
| rs34173062 | SHARPIN | GWAS association (p=2.0e-16) | Meta-analysis |
| rs983392 | — | GWAS association (p=6.0e-16) | Meta-analysis |
| rs4147929 | ABCA7 | GWAS association (p=1.0e-15) | Meta-analysis |
| rs62374257 | — | GWAS association (p=1.0e-15) | Meta-analysis |
| rs1902660 | TSPAN14 | GWAS association (p=1.0e-15) | Meta-analysis |
| rs602602 | — | GWAS association (p=2.0e-15) | Meta-analysis |
| rs4311 | ACE | GWAS association (p=2.0e-15) | Meta-analysis |
| rs56407236 | — | GWAS association (p=6.0e-15) | Meta-analysis |
| rs75680863 | TCN2 | GWAS association (p=1.0e-14) | Meta-analysis |
| rs1898895 | — | GWAS association (p=1.0e-14) | Meta-analysis |
| rs9394766 | — | GWAS association (p=2.0e-14) | Meta-analysis |
| rs11771145 | EPHA1-AS1 | GWAS association (p=3.0e-14) | Meta-analysis |
| rs57402520 | — | GWAS association (p=5.0e-14) | Meta-analysis |
| rs28834970 | PTK2B | GWAS association (p=7.0e-14) | Meta-analysis |
| rs7754282 | CD2AP | GWAS association (p=8.0e-14) | Meta-analysis |
| rs6827852 | — | GWAS association (p=2.0e-13) | Meta-analysis |
| rs7068231 | — | GWAS association (p=3.0e-13) | Meta-analysis |
| rs1140239 | DOC2A | GWAS association (p=3.0e-13) | Meta-analysis |
| rs79832570 | — | GWAS association (p=4.0e-13) | Meta-analysis |
| rs3804082 | OSBP2 | GWAS association (p=7.0e-13) | Meta-analysis |
| rs7935829 | — | GWAS association (p=8.0e-13) | Meta-analysis |
| rs2154481 | — | GWAS association (p=1.0e-12) | Meta-analysis |
| rs4434960 | — | GWAS association (p=1.0e-12) | Meta-analysis |
| rs9271192 | — | GWAS association (p=3.0e-12) | Meta-analysis |
| rs199498 | WNT3 | GWAS association (p=3.0e-12) | Meta-analysis |
| rs1859788 | PILRA | GWAS association (p=4.0e-12) | Meta-analysis |
| rs6117562 | — | GWAS association (p=2.0e-11) | Meta-analysis |
| rs11763230 | — | GWAS association (p=3.0e-11) | Meta-analysis |
| rs10948363 | CD2AP | GWAS association (p=5.0e-11) | Meta-analysis |
| rs13237518 | — | GWAS association (p=5.0e-11) | Meta-analysis |
| rs74825460 | FERMT2 | GWAS association (p=1.0e-10) | Meta-analysis |
| rs4407053 | — | GWAS association (p=1.0e-10) | Meta-analysis |
| rs1476679 | ZCWPW1 | GWAS association (p=6.0e-10) | Meta-analysis |
| rs1385742 | — | GWAS association (p=8.0e-10) | Meta-analysis |
| rs6682554 | — | GWAS association (p=9.0e-10) | Meta-analysis |
| rs2632516 | — | GWAS association (p=1.0e-09) | Meta-analysis |
| rs2245466 | — | GWAS association (p=1.0e-09) | Meta-analysis |
| rs1065712 | — | GWAS association (p=2.0e-09) | Meta-analysis |
| rs74504435 | — | GWAS association (p=2.0e-09) | Meta-analysis |
| rs2718058 | — | GWAS association (p=5.0e-09) | Meta-analysis |
| rs9381563 | — | GWAS association (p=5.0e-09) | Meta-analysis |
| rs78924645 | — | GWAS association (p=5.0e-09) | Meta-analysis |
| rs12576934 | LINC01499 | GWAS association (p=5.0e-09) | Meta-analysis |
| rs10498633 | SLC24A4 | GWAS association (p=6.0e-09) | Meta-analysis |
| rs12984029 | — | GWAS association (p=7.0e-09) | Meta-analysis |
| rs17125944 | FERMT2 | GWAS association (p=8.0e-09) | Meta-analysis |
| rs10838725 | CELF1 | GWAS association (p=1.0e-08) | Meta-analysis |
| rs1815157 | — | GWAS association (p=1.0e-08) | Meta-analysis |
| rs74093831 | — | GWAS association (p=1.0e-08) | Meta-analysis |
| rs67250450 | JAZF1 | GWAS association (p=1.0e-08) | Meta-analysis |
| rs732310 | — | GWAS association (p=1.0e-08) | Meta-analysis |
| rs111486601 | LOC105369990 | GWAS association (p=1.0e-08) | Meta-analysis |
| rs2741342 | CHRNA2 | GWAS association (p=1.0e-08) | Meta-analysis |
| rs11257242 | — | GWAS association (p=2.0e-08) | Meta-analysis |
| rs7657553 | — | GWAS association (p=2.0e-08) | Meta-analysis |
| rs4575098 | — | GWAS association (p=2.0e-08) | Meta-analysis |
| rs7274581 | CASS4 | GWAS association (p=3.0e-08) | Meta-analysis |
| rs35349669 | INPP5D | GWAS association (p=3.0e-08) | Meta-analysis |
| rs190982 | MEF2C-AS1 | GWAS association (p=3.0e-08) | Meta-analysis |
| rs9269853 | HLA-DRB1 | GWAS association (p=3.0e-08) | Meta-analysis |
| rs150622102 | ICA1L | GWAS association (p=3.0e-08) | Meta-analysis |
| rs3865444 | CD33 | GWAS association (p=4.0e-08) | Meta-analysis |
| rs4690221 | SLC26A1 | GWAS association (p=4.0e-08) | Meta-analysis |
| rs1997649 | — | GWAS association (p=4.0e-08) | Meta-analysis |
| rs1532278 | CLU | GWAS association (p=4.0e-08) | Meta-analysis |
| rs8093731 | — | GWAS association (p=5.0e-08) | Meta-analysis |
| rs117918145 | — | GWAS association (p=5.0e-08) | Meta-analysis |
| rs429358 | APOE | GWAS association (p=9.9e-324) | Meta-analysis |
| rs191177039 | SLC6A1 | GWAS association (p=9.0e-14) | Major Consortium Study |
| rs186375628 | — | GWAS association (p=8.0e-13) | Major Consortium Study |
| rs574718000 | TBXAS1 | GWAS association (p=8.0e-12) | Major Consortium Study |
Showing the top 100 of 472 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.