rs199498

This variant is located in the WNT3 gene.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroimaging measurement

Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele C
OR 0.11
p 3.0e-18
N 20,859
Major Consortium StudyLarge GWAS
European

schizophrenia, breast carcinoma

Tang M et al. “Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer.” Schizophrenia Bulletin 50(2):317-326 (2024)
Allele T
OR —
p 1.0e-12
N 377,817
Large GWAS
European

schizophrenia, estrogen-receptor positive breast cancer

Tang M et al. “Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer.” Schizophrenia Bulletin 50(2):317-326 (2024)
Allele T
OR —
p 1.0e-12
N 306,119
Large GWAS
European

Alzheimer disease

Lake J et al. “Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.” Molecular Psychiatry 28(7):3121-3132 (2023)
Allele T
OR —
p 3.0e-12
N 644,188
Meta-analysisLarge GWAS
multi-ancestry

erythrocyte attribute

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)
Allele C
OR 0.05
p 5.0e-10
N 39,566
Large GWAS
European

breast carcinoma

Michailidou K et al. “Association analysis identifies 65 new breast cancer risk loci.” Nature 551(7678):92-94 (2017)
Allele C
OR 0.04
p 2.0e-8
N 139,274
Large GWAS
multi-ancestry

About WNT3

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

View all WNT3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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