WNT3

Wnt family member 3

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

Known Variants114 total

rsidPosition (GRCh37)AllelesClassClinVar
rs19952817:44,843,136C/Tintron variant—
rs5772139717:44,845,446A/G—benign
rs7726616317:44,845,538C/T—likely benign
rs126572302317:44,845,703C/T—uncertain significance
rs37082105917:44,845,757T/C—uncertain significance
rs76760510317:44,845,785C/T—likely benign
rs15071798617:44,845,833G/A—likely benign
rs20031931817:44,845,839G/A—likely benign
rs13904053017:44,845,851A/G—likely benign
rs254598149417:44,845,877A/C—uncertain significance
rs78031828317:44,845,882C/T—uncertain significance
rs14989330817:44,845,911G/A—likely benign
rs90360243417:44,845,923G/A—likely benign
rs254598159617:44,845,926G/A—likely benign
rs74830648717:44,845,938C/T—likely benign
rs75305225417:44,845,944C/T—likely benign
rs37451122617:44,845,962C/T—likely benign
rs93090008117:44,845,980G/A—likely benign
rs254598174017:44,846,037G/A—likely benign
rs36866178217:44,846,043C/T—likely benign
rs254598174817:44,846,044T/C—uncertain significance
rs19950301517:44,846,064G/A—likely benign
rs37521003417:44,846,066T/C—uncertain significance
rs98319865317:44,846,112G/A—likely benign
rs78620588917:44,846,116C/T—uncertain significance
rs77774258217:44,846,172G/C—likely benign
rs7398702717:44,846,375C/T—likely benign
rs37156997117:44,847,129G/A—likely benign
rs20178511017:44,847,131G/A—likely benign
rs75533921617:44,847,136T/C—likely benign
rs37343611217:44,847,140C/T—likely benign
rs76953955817:44,847,185C/G—likely benign
rs76823827917:44,847,197C/T—likely benign
rs36993844617:44,847,209G/T—likely benign
rs76707034117:44,847,218C/T—likely benign
rs13990270117:44,847,219G/A—uncertain significance
rs214637481017:44,847,226C/G—uncertain significance
rs214637481417:44,847,227C/A—uncertain significance
rs14673902617:44,847,238A/G—likely benign
rs254598389117:44,847,253C/A—uncertain significance
rs254598391717:44,847,273C/G—uncertain significance
rs37091071717:44,847,293C/A—likely benign
rs74910825617:44,847,301T/C—uncertain significance
rs14890271617:44,847,308C/T—likely benign
rs147341589917:44,847,324A/G—uncertain significance
rs137024634017:44,847,341G/A—likely benign
rs76328343417:44,847,347G/C—uncertain significance
rs20157708717:44,847,359G/A—likely benign
rs254598409117:44,847,382C/T—uncertain significance
rs137462168217:44,847,421G/A—likely benign
rs134381962717:44,847,427C/A—likely benign
rs7332108317:44,847,666G/C—benign
rs19952617:44,847,707G/C—benign
rs19952517:44,847,834T/A——
rs380985717:44,848,314G/Tregulatory region variant—
rs19952317:44,848,517C/Aregulatory region variant—
rs74658355317:44,850,996A/C—benign
rs138622368617:44,851,000A/C—likely benign
rs156807664717:44,851,001G/C—likely benign
rs120603644317:44,851,006T/C—benign
rs20060907917:44,851,014C/G—likely benign
rs75368072717:44,851,016T/C—benign
rs121205825017:44,851,018A/C—likely benign
rs75496366317:44,851,019G/C—likely benign
rs254599082417:44,851,038G/A—likely benign
rs78077875017:44,851,046C/T—uncertain significance
rs74973794217:44,851,047G/T—conflicting classifications of pathogenicity
rs145276513617:44,851,070C/G—uncertain significance
rs78620588717:44,851,085A/Gmissense variantpathogenic
rs77244394917:44,851,096C/T—uncertain significance
rs77335869817:44,851,097G/A—uncertain significance
rs54789438317:44,851,098G/A—likely benign
rs148349414717:44,851,102C/T—uncertain significance
rs77681948917:44,851,103G/A—uncertain significance
rs10489465317:44,851,109G/Astop gainedpathogenic
rs117021081817:44,851,140G/A—likely benign
rs128531437617:44,851,195T/C—uncertain significance
rs37661033017:44,851,220C/T—uncertain significance
rs14360565717:44,851,221G/A—likely benign
rs37001689117:44,851,262C/T—uncertain significance
rs76524461617:44,851,285G/A—likely benign
rs37373868517:44,851,291G/T—likely benign
rs75144242717:44,851,292G/T—likely benign
rs19952117:44,853,456G/A——
rs19951917:44,853,924G/Aintron variant—
rs19951717:44,854,587A/Gintron variant—
rs6747424217:44,855,051A/C——
rs19951617:44,856,485C/G——
rs19951517:44,856,641G/Cregulatory region variant—
rs19951217:44,857,352T/G——
rs19951017:44,857,929A/Cintron variant—
rs41543017:44,859,144C/Tintron variant—
rs7060217:44,859,715T/Cregulatory region variant—
rs7060017:44,860,021C/G——
rs19950317:44,862,162G/Aintron variant—
rs207440417:44,865,439T/A——
rs19949817:44,865,603T/G——
rs19077600117:44,866,676C/Tintron variant—
rs55288525017:44,869,650G/C——
rs6673371117:44,887,849C/Tintron variant—

Showing 100 of 114 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.