rs199525

This variant is located in the WNT3 gene.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

intracranial volume measurement

Klein M et al. “Genetic Markers of ADHD-Related Variations in Intracranial Volume.” The American Journal of Psychiatry 176(3):228-238 (2019)
Allele T
OR 9.26
p 2.0e-20
N 24,024
Large GWAS
European

Fc receptor-like protein 2 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.04
p 1.0e-15
N 47,745
Large GWAS
European

vital capacity

Wyss AB et al. “Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.” Nature Communications 9(1):2976 (2018)
Allele T
OR 20.32
p 8.0e-9
N 90,715
Meta-analysisLarge GWAS
multi-ancestry

BMI-adjusted hip circumference

Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)
Allele G
OR 0.02
p 2.0e-8
N 219,872
Major Consortium StudyLarge GWAS
European

guilt measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele T
OR 5.51
p 4.0e-8
N 373,380
Large GWAS
European

forced expiratory volume

Wyss AB et al. “Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.” Nature Communications 9(1):2976 (2018)
Allele T
OR 19.16
p 2.0e-8
N 90,715
Meta-analysisLarge GWAS
multi-ancestry

About WNT3

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

View all WNT3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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