rs3804082
This is a intron variant variant in the OSBP2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Alzheimer disease
Ge YJ et al. “Genome-wide meta-analysis identifies ancestry-specific loci for Alzheimer's disease.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 20(9):6243-6256 (2024)
Allele A
OR 0.40
p 7.0e-13
N 2,809
Meta-analysis
multi-ancestry
About OSBP2
The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]
View all OSBP2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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