rs4663105

▶

GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease, family history of Alzheimer’s disease

Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)
Allele C
OR 13.94
p 3.0e-44
N 455,258
Meta-analysisLarge GWAS
European
Willett JDS et al. “Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(2):e14592 (2025)
Allele C
OR —
p 6.0e-11
N 404,467
Large GWAS
multi-ancestry

Alzheimer disease

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)
Allele C
OR 0.03
p 3.0e-39
N 640,258
Large GWAS
European
Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)
Allele C
OR 11.21
p 4.0e-29
N 79,145
Meta-analysisLarge GWAS
European
Jun G et al. “A novel Alzheimer disease locus located near the gene encoding tau protein.” Molecular Psychiatry 21(1):108-17 (2016)
Allele C
OR 1.19
p 2.0e-12
N 34,152
Large GWAS
European
Willett JDS et al. “Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(2):e14592 (2025)
Allele C
OR —
p 8.0e-11
N 27,907
Large GWAS
European, African unspecified, Hispanic or Latin American, Asian unspecified, NR
Talyansky S et al. “APOE-ε4 and BIN1 increase risk of Alzheimer's disease pathology but not specifically of Lewy body pathology.” Acta Neuropathologica Communications 11(1):149 (2023)
Allele C
OR 1.40
p 7.0e-10
N 3,755
Large GWAS
European

dementia

“A genome-wide association meta-analysis of all-cause and vascular dementia.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 20(9):5973-5995 (2024)
Allele C
OR 0.16
p 6.0e-34
N 510,615
Meta-analysisLarge GWAS
European

Alzheimer's disease biomarker measurement

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)
Allele C
OR 0.02
p 3.0e-27
N 568,836
Large GWAS
European

family history of Alzheimer’s disease

Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)
Allele C
OR 10.54
p 6.0e-26
N 376,113
Meta-analysisLarge GWAS
European

age of onset of Alzheimer disease

Li YJ et al. “Identification of novel genes for age-at-onset of Alzheimer's disease by combining quantitative and survival trait analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 19(7):3148-3157 (2023)
Allele C
OR 1.10
p 1.0e-19
N 19,564
Large GWAS
European

Lewy body dementia

Zhu P et al. “Genome-wide association study provides insights into the genetic basis of Lewy body dementia.” Molecular Psychiatry 30(12):5813-5827 (2025)
Allele A
OR 0.82
p 7.0e-12
N 8,953
Large GWAS
European

Alzheimer disease, Lewy body dementia

Talyansky S et al. “APOE-ε4 and BIN1 increase risk of Alzheimer's disease pathology but not specifically of Lewy body pathology.” Acta Neuropathologica Communications 11(1):149 (2023)
Allele C
OR 1.53
p 1.0e-10
N 2,335
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…