Trait

SNPs associated with age of onset of Alzheimer disease

27 genetic variants across 12 genes have been associated with age of onset of Alzheimer disease in published research. Key genes include ADRA1B, APOC1, APOE.

Associated variants27 total

rsidGeneEffectEvidence
rs6733839LOC105373605GWAS association (p=2.0e-37)Meta-analysis
rs10863417CR1GWAS association (p=1.0e-21)Meta-analysis
rs3041800—GWAS association (p=1.0e-14)Meta-analysis
rs62377696ADRA1BGWAS association (p=4.0e-12)Meta-analysis
rs472486—GWAS association (p=6.0e-12)Meta-analysis
rs6014722CASS4GWAS association (p=7.0e-12)Meta-analysis
rs73052335APOC1GWAS association (p=1.0e-10)Meta-analysis
rs9640386—GWAS association (p=1.0e-09)Meta-analysis
rs12539172—GWAS association (p=5.0e-09)Meta-analysis
rs1320688CATSPERZGWAS association (p=7.0e-09)Meta-analysis
rs34173062SHARPINGWAS association (p=8.0e-09)Meta-analysis
rs9395285—GWAS association (p=9.0e-09)Meta-analysis
rs7920721LOC105376412GWAS association (p=9.0e-09)Meta-analysis
rs10276423—GWAS association (p=2.0e-08)Meta-analysis
rs149428166—GWAS association (p=2.0e-08)Meta-analysis
rs1284402—GWAS association (p=2.0e-08)Meta-analysis
rs7412APOEGWAS association (p=8.0e-21)Large GWAS
rs4663105—GWAS association (p=1.0e-19)Large GWAS
rs75932628TREM2GWAS association (p=1.0e-13)Large GWAS
rs1408077CR1GWAS association (p=6.0e-10)Large GWAS
rs9808800DSCAMGWAS association (p=5.0e-09)Large GWAS
rs147145199ARFGEF2GWAS association (p=1.0e-08)Large GWAS
rs4725035—GWAS association (p=2.0e-08)Large GWAS
rs74855990—GWAS association (p=2.0e-08)Large GWAS
rs10792832—GWAS association (p=3.0e-08)Large GWAS
rs4861455—GWAS association (p=4.0e-08)Large GWAS
rs117834516—GWAS association (p=4.0e-08)Large GWAS

Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.

age of onset of Alzheimer disease — SNPs & genetic associations — Gene Wizard