rs6733839

This is a intergenic variant variant in the LOC105373605 gene.

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease

Bellenguez C et al. “New insights into the genetic etiology of Alzheimer's disease and related dementias.” Nature Genetics 54(4):412-436 (2022)
Allele T
OR 1.17
p 6.0e-118
N 487,511
Large GWAS
European
Lake J et al. “Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.” Molecular Psychiatry 28(7):3121-3132 (2023)
Allele T
OR —
p 6.0e-92
N 644,188
Meta-analysisLarge GWAS
multi-ancestry
Dalmasso MC et al. “The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 20(2):1298-1308 (2024)
Allele T
OR 1.18
p 4.0e-90
N 488,904
Large GWAS
multi-ancestry
Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)
Allele T
OR 11.30
p 1.0e-29
N 79,145
Meta-analysisLarge GWAS
European
Rajabli F et al. “Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.” Genome Biology 26(1):210 (2025)
Allele T
OR 1.12
p 7.0e-26
N 56,241
Meta-analysisLarge GWAS
multi-ancestry
Lambert JC et al. “Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.” Nature Genetics 45(12):1452-8 (2013)
Allele T
OR 1.22
p 7.0e-44
N 54,162
Meta-analysisLarge GWAS
European
Willett JDS et al. “Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(2):e14592 (2025)
Allele T
OR —
p 5.0e-11
N 27,907
Large GWAS
European, African unspecified, Hispanic or Latin American, Asian unspecified, NR
Jun G et al. “A novel Alzheimer disease locus located near the gene encoding tau protein.” Molecular Psychiatry 21(1):108-17 (2016)
Allele T
OR 1.20
p 1.0e-9
N 19,559
Large GWAS
European

age of onset of Alzheimer disease

Blue EE et al. “Multi-ancestry meta-analysis identifies genetic modifiers of age-at-onset of Alzheimer's disease at known and novel loci.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(9):e70489 (2025)
Allele T
OR 0.07
p 2.0e-37
N 41,527
Meta-analysisLarge GWAS
multi-ancestry

Alzheimer disease, family history of Alzheimer’s disease

Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)
Allele T
OR 11.30
p 1.0e-29
N 455,258
Meta-analysisLarge GWAS
European
Willett JDS et al. “Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(2):e14592 (2025)
Allele T
OR —
p 6.0e-12
N 404,467
Large GWAS
multi-ancestry

blood protein amount

Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)
Allele T
OR 0.15
p 3.0e-14
N 5,366
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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