CASS4
Cas scaffold protein family member 4
Summary
Enables protein tyrosine kinase binding activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; positive regulation of protein tyrosine kinase activity; and positive regulation of substrate adhesion-dependent cell spreading. Located in cytoplasm and focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants52 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs138191448 | 20:54,987,530 | A/G | — | likely benign |
| rs16979901 | 20:54,988,877 | A/G | intron variant | — |
| rs61482907 | 20:54,989,365 | C/T | intron variant | — |
| rs6014722 | 20:54,989,833 | T/G | — | — |
| rs55708816 | 20:54,990,124 | G/C | — | — |
| rs748253287 | 20:55,012,230 | C/A | — | uncertain significance |
| rs1304716845 | 20:55,012,301 | A/G | — | uncertain significance |
| rs1236494477 | 20:55,012,383 | G/A | — | uncertain significance |
| rs34102676 | 20:55,012,396 | C/T | — | benign |
| rs749520065 | 20:55,012,428 | C/A | — | uncertain significance |
| rs199573867 | 20:55,012,496 | C/T | — | likely benign |
| rs759957814 | 20:55,012,536 | G/A | — | uncertain significance |
| rs7274581 | 20:55,018,260 | T/A | — | — |
| rs757147059 | 20:55,021,046 | G/A | — | uncertain significance |
| rs558608299 | 20:55,025,719 | C/G | — | uncertain significance |
| rs1404979572 | 20:55,026,894 | T/C | — | likely benign |
| rs1177992598 | 20:55,026,941 | C/A | — | uncertain significance |
| rs944293988 | 20:55,026,969 | C/T | — | uncertain significance |
| rs73159591 | 20:55,026,995 | G/A | — | likely benign |
| rs372663259 | 20:55,027,005 | C/T | — | uncertain significance |
| rs367625281 | 20:55,027,023 | C/T | — | likely benign |
| rs774139936 | 20:55,027,029 | A/C | — | uncertain significance |
| rs754293038 | 20:55,027,058 | A/G | — | likely benign |
| rs2515959038 | 20:55,027,064 | A/G | — | uncertain significance |
| rs762438061 | 20:55,027,074 | A/G | — | likely benign |
| rs376819122 | 20:55,027,115 | A/T | — | uncertain significance |
| rs774792011 | 20:55,027,299 | C/T | — | likely benign |
| rs747825213 | 20:55,027,361 | G/A | — | likely benign |
| rs112730552 | 20:55,027,464 | C/G | — | likely benign |
| rs1981073474 | 20:55,027,506 | C/T | — | uncertain significance |
| rs34899200 | 20:55,027,509 | C/T | — | benign |
| rs1981076300 | 20:55,027,546 | T/A | — | uncertain significance |
| rs745392746 | 20:55,027,567 | G/A | — | uncertain significance |
| rs200228453 | 20:55,027,586 | G/A | — | uncertain significance |
| rs16979936 | 20:55,027,704 | G/A | — | benign |
| rs2515961508 | 20:55,027,761 | G/A | — | uncertain significance |
| rs529524026 | 20:55,027,814 | C/G | — | uncertain significance |
| rs148921681 | 20:55,027,815 | G/T | — | conflicting classifications of pathogenicity |
| rs779035230 | 20:55,027,935 | T/G | — | uncertain significance |
| rs151045039 | 20:55,027,970 | G/A | — | uncertain significance |
| rs199513148 | 20:55,028,000 | C/T | — | uncertain significance |
| rs1468997379 | 20:55,028,038 | A/G | — | likely benign |
| rs551061127 | 20:55,028,075 | C/T | — | uncertain significance |
| rs2870738 | 20:55,028,167 | G/C | — | uncertain significance |
| rs148206287 | 20:55,033,507 | G/A | — | uncertain significance |
| rs564292215 | 20:55,033,533 | C/G | — | uncertain significance |
| rs2515971333 | 20:55,033,552 | A/G | — | uncertain significance |
| rs369890182 | 20:55,033,556 | A/G | — | uncertain significance |
| rs2515971475 | 20:55,033,573 | A/G | — | uncertain significance |
| rs199741474 | 20:55,033,760 | A/G | — | uncertain significance |
| rs1435693423 | 20:55,033,777 | C/T | — | uncertain significance |
| rs7272702 | 20:55,033,782 | G/T | missense variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.