rs62377696

This is a regulatory region variant variant in the ADRA1B gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

age of onset of Alzheimer disease

Blue EE et al. “Multi-ancestry meta-analysis identifies genetic modifiers of age-at-onset of Alzheimer's disease at known and novel loci.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(9):e70489 (2025)
Allele A
OR —
β 0.042
p 4.0e-12
N 41,527
Meta-analysisLarge GWAS
multi-ancestry

About ADRA1B

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]

View all ADRA1B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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