ADRA1B
adrenoceptor alpha 1B
Summary
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs202245167 | 5:159,343,937 | C/T | — | uncertain significance |
| rs775000405 | 5:159,343,967 | G/C | — | uncertain significance |
| rs376465505 | 5:159,343,983 | A/C | — | uncertain significance |
| rs201086906 | 5:159,343,990 | T/C | — | likely benign |
| rs2532238424 | 5:159,344,090 | A/G | — | uncertain significance |
| rs767611485 | 5:159,344,334 | T/C | — | uncertain significance |
| rs781709695 | 5:159,344,387 | C/G | — | uncertain significance |
| rs367829656 | 5:159,344,456 | C/A | — | uncertain significance |
| rs751944506 | 5:159,344,469 | A/G | — | uncertain significance |
| rs2479886206 | 5:159,344,741 | A/C | — | uncertain significance |
| rs748079207 | 5:159,344,812 | C/G | — | likely benign |
| rs2030373 | 5:159,347,481 | C/G | — | — |
| rs6884105 | 5:159,348,443 | G/T | — | — |
| rs756275 | 5:159,351,460 | C/A | — | — |
| rs6892282 | 5:159,360,485 | G/A | — | — |
| rs10515807 | 5:159,364,998 | G/A | intron variant | — |
| rs13179079 | 5:159,367,009 | G/T | — | — |
| rs6888306 | 5:159,367,114 | C/A | — | — |
| rs13162302 | 5:159,367,275 | A/G | intron variant | — |
| rs11750092 | 5:159,367,971 | C/T | intron variant | — |
| rs62377696 | 5:159,378,506 | G/A | regulatory region variant | — |
| rs773919343 | 5:159,398,915 | G/A | — | uncertain significance |
| rs1581074590 | 5:159,399,033 | A/G | — | uncertain significance |
| rs201375864 | 5:159,399,037 | C/T | — | benign |
| rs1378899232 | 5:159,399,084 | G/A | — | uncertain significance |
| rs2480034335 | 5:159,399,099 | A/G | — | uncertain significance |
| rs957670819 | 5:159,399,104 | C/T | — | uncertain significance |
| rs1285891917 | 5:159,399,144 | G/T | — | uncertain significance |
| rs1466814495 | 5:159,399,210 | C/T | — | uncertain significance |
| rs994791314 | 5:159,399,213 | C/T | — | uncertain significance |
| rs1024446789 | 5:159,399,233 | C/G | — | uncertain significance |
| rs957724800 | 5:159,399,251 | G/T | — | uncertain significance |
| rs2480035183 | 5:159,399,270 | C/A | — | uncertain significance |
| rs2113300463 | 5:159,399,273 | A/C | — | uncertain significance |
| rs1336142226 | 5:159,399,275 | T/G | — | uncertain significance |
| rs911750399 | 5:159,399,321 | C/G | — | uncertain significance |
| rs1253682011 | 5:159,399,330 | G/T | — | uncertain significance |
| rs1050415172 | 5:159,399,368 | C/G | — | uncertain significance |
| rs1755895255 | 5:159,399,443 | G/A | — | uncertain significance |
| rs1332418848 | 5:159,399,473 | A/G | — | uncertain significance |
| rs148871069 | 5:159,404,471 | A/G | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.