rs10792832

This is a downstream gene variant variant.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease

Lake J et al. “Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.” Molecular Psychiatry 28(7):3121-3132 (2023)
Allele A
OR —
p 2.0e-40
N 644,188
Meta-analysisLarge GWAS
multi-ancestry
Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)
Allele A
OR 0.01
p 4.0e-9
N 1,486,094
Large GWAS
European
Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)
Allele A
OR 8.56
p 1.0e-17
N 79,145
Meta-analysisLarge GWAS
European
Lambert JC et al. “Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.” Nature Genetics 45(12):1452-8 (2013)
Allele A
OR 1.15
p 9.0e-26
N 54,162
Meta-analysisLarge GWAS
European

Alzheimer disease, family history of Alzheimer’s disease

Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)
Allele A
OR 8.61
p 7.0e-18
N 455,258
Meta-analysisLarge GWAS
European

family history of Alzheimer’s disease

Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)
Allele A
OR —
β 0.010
p 6.0e-9
N 376,113
Meta-analysisLarge GWAS
European

age of onset of Alzheimer disease

Li YJ et al. “Identification of novel genes for age-at-onset of Alzheimer's disease by combining quantitative and survival trait analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 19(7):3148-3157 (2023)
Allele A
OR 1.06
p 3.0e-8
N 19,564
Large GWAS
European

dementia

“A genome-wide association meta-analysis of all-cause and vascular dementia.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 20(9):5973-5995 (2024)
Allele A
OR —
β 0.074
p 4.0e-12
N 524,852
Meta-analysisLarge GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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