Trait
SNPs associated with family history of Alzheimer’s disease
20 genetic variants across 10 genes have been associated with family history of Alzheimer’s disease in published research. Key genes include ABCA7, APOE, BCL3.
Associated variants20 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs75627662 | — | GWAS association (p=1.0e-295) | Meta-analysis |
| rs4663105 | — | GWAS association (p=6.0e-26) | Meta-analysis |
| rs187370608 | LOC101929555 | GWAS association (p=2.0e-16) | Meta-analysis |
| rs3844143 | — | GWAS association (p=5.0e-11) | Meta-analysis |
| rs7384878 | — | GWAS association (p=2.0e-10) | Meta-analysis |
| rs679515 | CR1 | GWAS association (p=9.0e-10) | Meta-analysis |
| rs1476679 | ZCWPW1 | GWAS association (p=1.0e-09) | Meta-analysis |
| rs114360492 | CNTNAP2 | GWAS association (p=2.0e-09) | Meta-analysis |
| rs6656401 | CR1 | GWAS association (p=4.0e-09) | Meta-analysis |
| rs1582763 | — | GWAS association (p=5.0e-09) | Meta-analysis |
| rs10792832 | — | GWAS association (p=6.0e-09) | Meta-analysis |
| rs1532278 | CLU | GWAS association (p=7.0e-09) | Meta-analysis |
| rs6448451 | — | GWAS association (p=1.0e-08) | Meta-analysis |
| rs184384746 | — | GWAS association (p=1.0e-08) | Meta-analysis |
| rs3752241 | ABCA7 | GWAS association (p=3.0e-08) | Meta-analysis |
| rs9916042 | — | GWAS association (p=5.0e-08) | Meta-analysis |
| rs188552176 | NCR1 | GWAS association (p=5.0e-11) | Major Consortium Study |
| rs429358 | APOE | GWAS association (p=9.9e-324) | Major Consortium Study |
| rs561654715 | TOMM40 | GWAS association (p=6.0e-17) | Large GWAS |
| rs114036675 | BCL3 | GWAS association (p=9.0e-12) | Large GWAS |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.