BCL3
BCL3 transcription coactivator
Summary
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
Known Variants38 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2965169 | 19:45,251,156 | A/C | regulatory region variant | — |
| rs531660643 | 19:45,251,806 | G/T | — | — |
| rs1409945901 | 19:45,252,055 | G/A | — | uncertain significance |
| rs1000886222 | 19:45,252,111 | G/A | — | uncertain significance |
| rs969258640 | 19:45,252,154 | C/T | — | uncertain significance |
| rs1967120125 | 19:45,252,177 | C/A | — | uncertain significance |
| rs868370649 | 19:45,252,180 | G/A | — | uncertain significance |
| rs932958438 | 19:45,252,181 | C/A | — | uncertain significance |
| rs2513612823 | 19:45,252,183 | G/T | — | uncertain significance |
| rs768745302 | 19:45,252,199 | C/A | — | uncertain significance |
| rs762620688 | 19:45,252,229 | G/A | — | uncertain significance |
| rs1310134646 | 19:45,252,240 | G/A | — | uncertain significance |
| rs759505305 | 19:45,252,250 | C/T | — | uncertain significance |
| rs779203246 | 19:45,252,283 | C/T | — | uncertain significance |
| rs373183384 | 19:45,252,291 | C/G | — | uncertain significance |
| rs8100239 | 19:45,253,104 | T/A | regulatory region variant | — |
| rs373600361 | 19:45,254,542 | C/A | — | uncertain significance |
| rs760615560 | 19:45,254,562 | C/A | — | uncertain significance |
| rs140257795 | 19:45,254,603 | G/A | — | uncertain significance |
| rs745707405 | 19:45,254,616 | G/A | — | uncertain significance |
| rs62117205 | 19:45,255,266 | T/C | intron variant | — |
| rs62117206 | 19:45,255,679 | G/C | intron variant | — |
| rs772518779 | 19:45,259,587 | A/G | — | uncertain significance |
| rs1398101495 | 19:45,259,593 | G/A | — | uncertain significance |
| rs35980686 | 19:45,260,350 | T/C | — | benign |
| rs138512809 | 19:45,260,394 | G/C | — | uncertain significance |
| rs763828094 | 19:45,260,419 | G/A | — | uncertain significance |
| rs369753256 | 19:45,260,631 | G/A | — | uncertain significance |
| rs2513620471 | 19:45,260,662 | T/G | — | uncertain significance |
| rs35211322 | 19:45,260,971 | G/T | — | benign |
| rs34401216 | 19:45,261,520 | C/T | — | benign |
| rs1264446297 | 19:45,262,108 | C/T | — | likely benign |
| rs114036675 | 19:45,262,696 | G/A | missense variant | — |
| rs745458470 | 19:45,262,726 | C/T | — | uncertain significance |
| rs150051050 | 19:45,262,754 | T/C | — | uncertain significance |
| rs1967380597 | 19:45,262,759 | C/G | — | uncertain significance |
| rs377071242 | 19:45,262,838 | C/A | — | uncertain significance |
| rs543205423 | 19:45,262,862 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.