rs11771145

This variant is located in the EPHA1-AS1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease

Bellenguez C et al. “New insights into the genetic etiology of Alzheimer's disease and related dementias.” Nature Genetics 54(4):412-436 (2022)

Allele A

OR 0.95

p 3.0e-14

N 487,511

Large GWAS

European

Lake J et al. “Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.” Molecular Psychiatry 28(7):3121-3132 (2023)

Allele A

OR —

p 5.0e-13

N 644,188

Meta-analysisLarge GWAS

multi-ancestry

Dalmasso MC et al. “The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 20(2):1298-1308 (2024)

Allele A

OR 0.94

p 1.0e-12

N 488,904

Large GWAS

multi-ancestry

Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)

Allele A

OR 5.49

p 4.0e-8

N 79,145

Meta-analysisLarge GWAS

European

Lambert JC et al. “Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.” Nature Genetics 45(12):1452-8 (2013)

Allele A

OR 1.11

p 1.0e-13

N 54,162

Meta-analysisLarge GWAS

European

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Research that mentions this SNP (1)

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Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

AssociationN=35,000Seshadri S. et al.(2010)· JAMA

This 3-stage genome-wide association meta-analysis study identified 5 novel and confirmed loci associated with late-onset Alzheimer's disease across over 35,000 individuals. The study discovered two new genome-wide significant loci: rs744373 in BIN1 (OR 1.13, p=1.59×10⁻¹¹) and rs597668 near EXOC3L2 (OR 1.18, p=6.45×10⁻⁹), and confirmed three previously reported loci in APOE (OR 2.53, p=1.04×10⁻²⁹⁵), CLU (OR 0.85, p=1.62×10⁻¹⁶), and PICALM (OR 0.89, p=3.16×10⁻¹²). These findings were validated in an independent Spanish replication sample of 2,349 individuals.

Traits studied:Alzheimer's diseaseLate-onset Alzheimer's disease

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs11771145

GWAS Catalog Trait Associations (1)

Alzheimer disease

Research that mentions this SNP (1)

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