rs9331896
This variant is located in the CLU gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Alzheimer disease
Lambert JC et al. “Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.” Nature Genetics 45(12):1452-8 (2013)
Allele T
OR 1.16
p 3.0e-25
N 54,162
Meta-analysisLarge GWAS
European
Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)
Allele T
OR 8.82
p 1.0e-18
N 79,145
Meta-analysisLarge GWAS
European
Jun G et al. “A novel Alzheimer disease locus located near the gene encoding tau protein.” Molecular Psychiatry 21(1):108-17 (2016)
Allele T
OR 1.19
p 3.0e-9
N 19,559
Large GWAS
European
Alzheimer disease, family history of Alzheimer’s disease
Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)
Allele C
OR 8.35
p 7.0e-17
N 455,258
Meta-analysisLarge GWAS
European
About CLU
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]
View all CLU variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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