CELF1

CUGBP Elav-like family member 1

Summary

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Known Variants31 total

rsidPosition (GRCh37)AllelesClassClinVar
rs14549580711:47,493,806C/Tbenign
rs76728867711:47,493,859T/Cuncertain significance
rs1103925511:47,495,746G/Tintron variant
rs119884274911:47,496,989T/Cuncertain significance
rs249733374711:47,496,995T/Cuncertain significance
rs249734408211:47,497,055C/Tuncertain significance
rs14534069711:47,498,415T/Cuncertain significance
rs1222467211:47,500,400C/Tintron variant
rs5768074211:47,501,888C/Tintron variant
rs249921209411:47,505,064T/Cuncertain significance
rs77950153411:47,505,956C/Tuncertain significance
rs77617692211:47,506,012C/Tuncertain significance
rs77620050611:47,508,336T/Cuncertain significance
rs74768967911:47,508,338T/Cuncertain significance
rs249990365011:47,508,766C/Auncertain significance
rs20090141111:47,510,458C/Tuncertain significance
rs119008968611:47,510,547T/Guncertain significance
rs794502111:47,512,138G/Aupstream gene variant
rs1103926511:47,523,214C/T
rs220371211:47,534,964T/Cregulatory region variant
rs7444544111:47,538,134T/Aupstream gene variant
rs1083872511:47,557,871T/Cintron variant
rs6189511111:47,558,516C/Tintron variant
rs8022160611:47,560,211A/T
rs1103928311:47,563,354G/T
rs1083872611:47,568,344C/Gintron variant
rs1222505111:47,571,967C/Tintron variant
rs7147592111:47,573,342G/Aintron variant
rs286899611:47,575,370A/T
rs2836476911:47,575,372T/C
rs1153775111:47,587,452C/Tsplice region variant

Gene information from NCBI Gene. Variant classifications from ClinVar.