NECTIN2
nectin cell adhesion molecule 2
Summary
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Known Variants90 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4452060 | 19:45,347,911 | C/A | regulatory region variant | — |
| rs2927472 | 19:45,349,369 | T/C | regulatory region variant | — |
| rs3810143 | 19:45,349,402 | T/C | regulatory region variant | — |
| rs759104249 | 19:45,354,618 | C/A | — | — |
| rs76205446 | 19:45,355,267 | T/A | intron variant | — |
| rs149661872 | 19:45,355,288 | C/T | intron variant | — |
| rs4803764 | 19:45,357,377 | T/C | intron variant | — |
| rs2927468 | 19:45,357,939 | A/G | intron variant | — |
| rs143459034 | 19:45,358,026 | C/A | — | — |
| rs551048812 | 19:45,358,306 | C/T | — | — |
| rs4803765 | 19:45,358,448 | C/T | intron variant | — |
| rs12462573 | 19:45,359,706 | G/A | regulatory region variant | — |
| rs375972689 | 19:45,360,488 | T/G | — | — |
| rs139989004 | 19:45,361,769 | G/T | — | — |
| rs2436474 | 19:45,362,269 | G/T | intron variant | — |
| rs387369 | 19:45,363,254 | G/A | intron variant | — |
| rs403155 | 19:45,363,299 | C/T | intron variant | — |
| rs384973 | 19:45,363,791 | T/C | — | — |
| rs138607350 | 19:45,363,820 | T/G | intron variant | — |
| rs411856 | 19:45,364,623 | C/T | intron variant | — |
| rs395710 | 19:45,364,815 | A/G | intron variant | — |
| rs538568659 | 19:45,365,042 | A/G | — | — |
| rs555608 | 19:45,365,072 | A/G | intron variant | — |
| rs2436475 | 19:45,365,248 | T/C | intron variant | — |
| rs11669109 | 19:45,365,476 | T/C | intron variant | — |
| rs12980631 | 19:45,365,641 | A/T | — | — |
| rs11665829 | 19:45,365,817 | G/A | intron variant | — |
| rs416116 | 19:45,366,345 | G/A | intron variant | — |
| rs183427010 | 19:45,366,498 | G/A | intron variant | — |
| rs521629 | 19:45,366,603 | G/A | intron variant | — |
| rs519825 | 19:45,366,779 | T/C | intron variant | — |
| rs376208680 | 19:45,368,518 | C/T | — | likely benign |
| rs536775165 | 19:45,368,563 | G/A | — | uncertain significance |
| rs1365743374 | 19:45,368,566 | C/T | — | uncertain significance |
| rs199754326 | 19:45,368,578 | G/A | — | uncertain significance |
| rs149820842 | 19:45,368,586 | C/T | — | likely benign |
| rs113179384 | 19:45,368,598 | G/A | — | likely benign |
| rs201817533 | 19:45,368,727 | G/A | — | likely benign |
| rs1279274056 | 19:45,368,802 | G/A | — | likely benign |
| rs34929997 | 19:45,368,805 | C/T | — | benign |
| rs916044396 | 19:45,368,811 | G/A | — | likely benign |
| rs565566 | 19:45,370,570 | A/C | intron variant | — |
| rs564724 | 19:45,370,649 | A/T | — | — |
| rs510297 | 19:45,370,673 | C/T | — | — |
| rs113793098 | 19:45,372,798 | C/G | — | — |
| rs79074020 | 19:45,374,350 | T/C | intron variant | — |
| rs145915904 | 19:45,375,147 | G/A | — | benign |
| rs146534542 | 19:45,375,157 | G/C | — | benign |
| rs41290104 | 19:45,375,164 | C/T | — | likely benign |
| rs777165380 | 19:45,375,273 | C/T | — | likely benign |
| rs148321526 | 19:45,375,295 | C/T | — | likely benign |
| rs187183066 | 19:45,375,585 | A/G | intron variant | — |
| rs519113 | 19:45,376,284 | C/A | — | — |
| rs764175486 | 19:45,377,219 | C/T | — | likely benign |
| rs149575863 | 19:45,377,254 | G/A | — | benign |
| rs74533957 | 19:45,377,605 | G/A | — | likely benign |
| rs139448288 | 19:45,377,611 | C/T | — | likely benign |
| rs138914864 | 19:45,379,431 | C/T | regulatory region variant | — |
| rs3865427 | 19:45,380,961 | C/A | downstream gene variant | — |
| rs150639620 | 19:45,381,292 | G/T | downstream gene variant | — |
| rs568573967 | 19:45,381,359 | T/A | — | — |
| rs201037066 | 19:45,381,530 | G/A | — | benign |
| rs773661475 | 19:45,381,532 | G/T | — | likely benign |
| rs753238889 | 19:45,381,607 | G/A | — | likely benign |
| rs148423386 | 19:45,381,676 | G/A | — | likely benign |
| rs6859 | 19:45,382,034 | A/T | — | — |
| rs73050302 | 19:45,382,996 | C/G | — | — |
| rs1985129 | 19:45,384,338 | G/A | — | — |
| rs369077933 | 19:45,385,421 | T/C | coding sequence variant | — |
| rs187706273 | 19:45,385,488 | G/A | — | benign |
| rs539311376 | 19:45,385,594 | C/T | — | uncertain significance |
| rs3745151 | 19:45,385,918 | G/T | — | — |
| rs166907 | 19:45,386,855 | A/G | regulatory region variant | — |
| rs283808 | 19:45,387,034 | A/C | intron variant | — |
| rs283811 | 19:45,388,500 | A/G | intron variant | — |
| rs562961456 | 19:45,388,678 | T/C | — | — |
| rs1966960 | 19:45,389,198 | G/C | — | benign |
| rs571919329 | 19:45,389,208 | C/T | — | likely benign |
| rs372667207 | 19:45,389,371 | C/T | upstream gene variant | — |
| rs191568940 | 19:45,389,381 | C/T | — | benign |
| rs376996543 | 19:45,389,419 | G/A | — | likely benign |
| rs182813625 | 19:45,389,449 | T/C | — | likely benign |
| rs527428691 | 19:45,389,633 | C/T | — | — |
| rs283815 | 19:45,390,333 | A/G | upstream gene variant | — |
| rs148665049 | 19:45,391,132 | C/T | upstream gene variant | — |
| rs1276887019 | 19:45,391,380 | A/G | — | uncertain significance |
| rs367823329 | 19:45,391,418 | T/C | — | benign |
| rs368065414 | 19:45,391,434 | C/T | — | uncertain significance |
| rs145654351 | 19:45,391,454 | C/T | missense variant | — |
| rs6857 | 19:45,392,254 | C/T | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.