rs12447915

This is a intron variant variant in the PPP4C gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

substance-related disorder

Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)

Allele T

OR 7.51

p 6.0e-14

N 1,458,999

Large GWAS

European

About PPP4C

Enables protein serine/threonine phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in several cellular components, including chromatin; cytosol; and nucleoplasm. Part of protein phosphatase 4 complex. [provided by Alliance of Genome Resources, Jul 2025]

View all PPP4C variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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