rs6589386
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
substance-related disorder
Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)
Allele T
OR 10.63
p 2.0e-26
N 1,517,369
Large GWAS
multi-ancestry
Hatoum AS et al. “Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.” Nature. Mental Health 1(3):210-223 (2023)
Allele T
OR —
β 0.017
p 3.0e-12
N 647,703
Meta-analysisLarge GWAS
European
alcohol use disorder measurement, alcohol consumption quality
Zhou H et al. “Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.” Nature Neuroscience 23(7):809-818 (2020)
Allele T
OR 0.02
p 3.0e-18
N 972,915
Meta-analysisLarge GWAS
European
cannabis dependence
Levey DF et al. “Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.” Nature Genetics 55(12):2094-2103 (2023)
Allele T
OR 0.02
p 2.0e-12
N 200,762
Large GWAS
European
alcohol use disorder measurement
Zhou H et al. “Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.” Nature Neuroscience 23(7):809-818 (2020)
Allele T
OR 6.86
p 7.0e-12
N 313,959
Meta-analysisLarge GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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