rs61905747
This is a downstream gene variant variant in the ZW10 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
substance-related disorder
Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)
Allele A
OR 7.23
p 5.0e-13
N 1,517,369
Large GWAS
multi-ancestry
aging
Rosoff DB et al. “Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.” Nature Aging 3(8):1020-1035 (2023)
Allele A
OR 0.01
p 2.0e-10
N 1,559,001
Large GWAS
European
healthspan, parental longevity, life span determination trait
Timmers PRHJ et al. “Multivariate genomic scan implicates novel loci and haem metabolism in human ageing.” Nature Communications 11(1):3570 (2020)
Allele A
OR —
p 4.0e-10
N 837,415
Large GWAS
European
parental longevity
Pilling LC et al. “Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.” Aging 9(12):2504-2520 (2017)
Allele A
OR 0.02
p 6.0e-9
N 415,311
Major Consortium StudyLarge GWAS
European
About ZW10
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
View all ZW10 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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