rs6794924

This variant is located in the IHO1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

substance-related disorder

Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)

Allele A

OR 9.66

p 4.0e-22

N 1,458,999

Large GWAS

European

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele A

OR 0.01

p 4.0e-16

N 3,382,012

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

About IHO1

Predicted to be involved in several processes, including meiosis I cell cycle process; regulation of homologous chromosome segregation; and spermatogenesis. Predicted to be located in chromosome. Predicted to be active in condensed nuclear chromosome. [provided by Alliance of Genome Resources, Jul 2025]

View all IHO1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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