rs11642015
This variant is located in the FTO gene.
▶GWAS Catalog Trait Associations (48)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (48)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
body mass index
Hawkes G et al. “Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.” Diabetologia 66(8):1472-1480 (2023)
Allele C
OR 0.07
p 4.0e-315
N 441,761
Large GWAS
European
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.07
p 9.0e-290
N 523,818
Large GWAS
multi-ancestry
Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)
Allele C
OR 0.08
p 2.0e-213
N 342,566
Large GWAS
European
Akiyama M et al. “Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.” Nature Genetics 49(10):1458-1467 (2017)
Allele C
OR 0.08
p 2.0e-81
N 158,284
Large GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.11
p 4.0e-55
N 57,796
Major Consortium StudyLarge GWAS
Hispanic or Latin American
body fat percentage
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.04
p 2.0e-170
N 394,642
Large GWAS
European
Wong HS et al. “Genome-wide association study identifies genetic risk loci for adiposity in a Taiwanese population.” Plos Genetics 18(1):e1009952 (2022)
Allele T
OR 0.04
p 1.0e-112
N 538,459
Large GWAS
multi-ancestry
Martin S et al. “Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease.” Diabetes 70(8):1843-1856 (2021)
Allele T
OR —
β 0.041
p 7.0e-165
N 442,278
Large GWAS
European
waist circumference
Wong HS et al. “Genome-wide association study identifies genetic risk loci for adiposity in a Taiwanese population.” Plos Genetics 18(1):e1009952 (2022)
Allele C
OR 0.06
p 5.0e-167
N 607,602
Large GWAS
multi-ancestry
fat pad mass
Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)
Allele T
OR 0.07
p 3.0e-163
N 337,196
Large GWAS
European
obesity
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.14
p 5.0e-162
N 585,585
Major Consortium StudyLarge GWAS
multi-ancestry
aspartate aminotransferase measurement, low density lipoprotein triglyceride measurement, serum alanine aminotransferase amount, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement
Martin S et al. “Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease.” Diabetes 70(8):1843-1856 (2021)
Allele T
OR —
p 2.0e-157
N 389,354
Large GWAS
European
type 2 diabetes mellitus
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.12
p 2.0e-95
N 612,947
Major Consortium StudyLarge GWAS
multi-ancestry
Ishigaki K et al. “Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.” Nature Genetics 52(7):669-679 (2020)
Allele C
OR 1.14
p 1.0e-35
N 210,865
Large GWAS
East Asian
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.12
p 6.0e-27
N 177,415
Large GWAS
East Asian
body weight
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.10
p 7.0e-51
N 57,954
Major Consortium StudyLarge GWAS
Hispanic or Latin American
grip strength measurement
Tikkanen E et al. “Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank.” Scientific Reports 8(1):6451 (2018)
Allele T
OR 0.00
p 8.0e-49
N 334,825
Major Consortium StudyLarge GWAS
European
sleep apnea
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.08
p 7.0e-45
N 315,668
Major Consortium StudyLarge GWAS
European
About FTO
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
View all FTO variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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