Trait
SNPs associated with Obesity
207 genetic variants across 71 genes have been associated with Obesity in published research. Key genes include ADCY3, ADCY9, ADH1B.
Associated variants207 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs1421085 | FTO | Disrupts adipocyte thermogenesis increasing obesity risk | Meta-analysis |
| rs8043757 | FTO | GWAS association (p=5.0e-110) | Meta-analysis |
| rs1558902 | FTO | GWAS association (p=2.0e-81) | Meta-analysis |
| rs7185735 | FTO | GWAS association (p=1.0e-79) | Meta-analysis |
| rs6567160 | — | GWAS association (p=1.0e-42) | Meta-analysis |
| rs538656 | — | GWAS association (p=2.0e-36) | Meta-analysis |
| rs10938397 | — | GWAS association (p=3.0e-34) | Meta-analysis |
| rs1800437 | GIPR | GWAS association (p=5.0e-34) | Meta-analysis |
| rs7132908 | FAIM2 | GWAS association (p=6.0e-30) | Meta-analysis |
| rs10871777 | — | GWAS association (p=2.0e-27) | Meta-analysis |
| rs56094641 | — | GWAS association (p=6.0e-25) | Meta-analysis |
| rs10189761 | — | GWAS association (p=6.0e-24) | Meta-analysis |
| rs11152213 | — | GWAS association (p=3.0e-22) | Meta-analysis |
| rs2206277 | TFAP2B | GWAS association (p=5.0e-22) | Meta-analysis |
| rs7138803 | — | GWAS association (p=1.0e-20) | Meta-analysis |
| rs2207139 | — | GWAS association (p=3.0e-19) | Meta-analysis |
| rs2307111 | POC5 | GWAS association (p=5.0e-19) | Meta-analysis |
| rs7579427 | — | GWAS association (p=4.0e-18) | Meta-analysis |
| rs7141420 | NRXN3 | GWAS association (p=1.0e-17) | Meta-analysis |
| rs10182181 | — | GWAS association (p=1.0e-17) | Meta-analysis |
| rs7531118 | LOC105378797 | GWAS association (p=2.0e-17) | Meta-analysis |
| rs2568958 | LOC105378797 | GWAS association (p=4.0e-16) | Meta-analysis |
| rs539515 | — | GWAS association (p=4.0e-14) | Meta-analysis |
| rs3101336 | LOC105378797 | GWAS association (p=2.0e-08) | Meta-analysis |
| rs7498665 | SH2B1 | GWAS association (p=3.0e-13) | Meta-analysis |
| rs10423928 | GIPR | GWAS association (p=4.0e-13) | Meta-analysis |
| rs8028313 | MAP2K5 | GWAS association (p=6.0e-13) | Meta-analysis |
| rs12446554 | LOC105371116 | GWAS association (p=4.0e-12) | Meta-analysis |
| rs17024258 | GNAT2 | GWAS association (p=9.0e-12) | Meta-analysis |
| rs11042023 | TRIM66 | GWAS association (p=1.0e-11) | Meta-analysis |
| rs4077678 | ADCY3 | GWAS association (p=1.0e-11) | Meta-analysis |
| rs987237 | TFAP2B | GWAS association (p=2.0e-11) | Meta-analysis |
| rs10493544 | — | GWAS association (p=2.0e-11) | Meta-analysis |
| rs13078807 | CADM2 | GWAS association (p=3.0e-11) | Meta-analysis |
| rs887912 | — | GWAS association (p=1.0e-10) | Meta-analysis |
| rs1412239 | LINGO2 | GWAS association (p=2.0e-10) | Meta-analysis |
| rs12446632 | LOC105371116 | GWAS association (p=2.0e-10) | Meta-analysis |
| rs10875976 | BCDIN3D-AS1 | GWAS association (p=2.0e-10) | Meta-analysis |
| rs4735692 | — | GWAS association (p=4.0e-10) | Meta-analysis |
| rs9568867 | — | GWAS association (p=2.0e-09) | Meta-analysis |
| rs6731302 | LINC01122 | GWAS association (p=2.0e-09) | Meta-analysis |
| rs1516725 | ETV5 | GWAS association (p=3.0e-09) | Meta-analysis |
| rs2370983 | NRXN3 | GWAS association (p=3.0e-09) | Meta-analysis |
| rs11639988 | — | GWAS association (p=4.0e-09) | Meta-analysis |
| rs2112347 | POC5 | GWAS association (p=4.0e-09) | Meta-analysis |
| rs1514177 | TNNI3K | GWAS association (p=5.0e-09) | Meta-analysis |
| rs7184597 | RABEP2 | GWAS association (p=7.0e-09) | Meta-analysis |
| rs7826222 | — | GWAS association (p=9.0e-09) | Meta-analysis |
| rs7989336 | HS6ST3 | GWAS association (p=1.0e-08) | Meta-analysis |
| rs1514174 | TNNI3K | GWAS association (p=1.0e-08) | Meta-analysis |
| rs7503807 | RPTOR | GWAS association (p=2.0e-08) | Meta-analysis |
| rs13041126 | LOC105372666 | GWAS association (p=2.0e-08) | Meta-analysis |
| rs2605100 | LYPLAL1-AS1 | GWAS association (p=3.0e-08) | Meta-analysis |
| rs17381664 | ZZZ3 | GWAS association (p=3.0e-08) | Meta-analysis |
| rs10968576 | LINGO2 | GWAS association (p=3.0e-08) | Meta-analysis |
| rs2531995 | ADCY9 | GWAS association (p=4.0e-08) | Meta-analysis |
| rs74583214 | — | GWAS association (p=5.0e-08) | Meta-analysis |
| rs114670539 | — | GWAS association (p=5.0e-08) | Meta-analysis |
| rs1121980 | FTO | Each T allele increases obesity risk by ~20% | Meta-analysis |
| rs1799883 | FABP2 | Increased obesity risk | Meta-analysis |
| rs633715 | — | GWAS association (p=9.0e-23) | Meta-analysis |
| rs2030323 | BDNF | GWAS association (p=3.0e-22) | Meta-analysis |
| rs9816226 | — | GWAS association (p=2.0e-14) | Meta-analysis |
| rs6711012 | — | GWAS association (p=3.0e-40) | Meta-analysis |
| rs13130484 | — | GWAS association (p=1.0e-51) | Meta-analysis |
| rs11642015 | FTO | GWAS association (p=5.0e-162) | Major Consortium Study |
| rs13107325 | SLC39A8 | GWAS association (p=6.0e-51) | Major Consortium Study |
| rs35796073 | — | GWAS association (p=8.0e-33) | Major Consortium Study |
| rs2568952 | LOC105378797 | GWAS association (p=9.0e-33) | Major Consortium Study |
| rs10953513 | — | GWAS association (p=2.0e-28) | Major Consortium Study |
| rs76880877 | ETV5 | GWAS association (p=2.0e-27) | Major Consortium Study |
| rs4858697 | — | GWAS association (p=2.0e-25) | Major Consortium Study |
| rs62037364 | — | GWAS association (p=2.0e-24) | Major Consortium Study |
| rs4776970 | MAP2K5 | GWAS association (p=4.0e-24) | Major Consortium Study |
| rs11039405 | NUP160 | GWAS association (p=6.0e-24) | Major Consortium Study |
| rs2238435 | ADCY9 | GWAS association (p=7.0e-24) | Major Consortium Study |
| rs34783010 | — | GWAS association (p=7.0e-24) | Major Consortium Study |
| rs34872471 | TCF7L2 | GWAS association (p=3.0e-23) | Major Consortium Study |
| rs10150332 | NRXN3 | GWAS association (p=2.0e-22) | Major Consortium Study |
| rs7969447 | C12orf42 | GWAS association (p=4.0e-22) | Major Consortium Study |
| rs6265 | BDNF | GWAS association (p=1.0e-21) | Major Consortium Study |
| rs17770336 | LINGO2 | GWAS association (p=2.0e-21) | Major Consortium Study |
| rs543874 | — | GWAS association (p=2.0e-20) | Major Consortium Study |
| rs34517439 | — | GWAS association (p=6.0e-19) | Major Consortium Study |
| rs34811474 | — | GWAS association (p=6.0e-19) | Major Consortium Study |
| rs4923464 | — | GWAS association (p=2.0e-18) | Major Consortium Study |
| rs17817964 | FTO | GWAS association (p=6.0e-18) | Major Consortium Study |
| rs2306593 | — | GWAS association (p=1.0e-17) | Major Consortium Study |
| rs12739556 | LOC105378866 | GWAS association (p=1.0e-17) | Major Consortium Study |
| rs7903146 | TCF7L2 | GWAS association (p=3.0e-17) | Major Consortium Study |
| rs45486197 | — | GWAS association (p=4.0e-17) | Major Consortium Study |
| rs17770163 | LINGO2 | GWAS association (p=2.0e-16) | Major Consortium Study |
| rs61765646 | NEGR1 | GWAS association (p=3.0e-16) | Major Consortium Study |
| rs429358 | APOE | GWAS association (p=7.0e-16) | Major Consortium Study |
| rs1296328 | — | GWAS association (p=1.0e-15) | Major Consortium Study |
| rs1556036 | — | GWAS association (p=3.0e-15) | Major Consortium Study |
| rs1861412 | LINC01122 | GWAS association (p=3.0e-15) | Major Consortium Study |
| rs62477684 | POM121C | GWAS association (p=4.0e-15) | Major Consortium Study |
| rs147199209 | — | GWAS association (p=6.0e-15) | Major Consortium Study |
| rs7160809 | — | GWAS association (p=1.0e-14) | Major Consortium Study |
Showing the top 100 of 207 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.