rs7531118
This is a intergenic variant variant in the LOC105378797 gene.
▶GWAS Catalog Trait Associations (9)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (9)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
major depressive disorder
Als TD et al. “Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.” Nature Medicine 29(7):1832-1844 (2023)
Allele T
OR 0.03
p 1.0e-27
N 1,349,887
Large GWAS
European
alcohol consumption quality
Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele C
OR 0.01
p 2.0e-20
N 2,965,643
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified
obesity
Berndt SI et al. “Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.” Nature Genetics 45(5):501-12 (2013)
Allele C
OR 1.08
p 2.0e-17
N 204,498
Meta-analysisLarge GWAS
European
bipolar disorder, major depressive disorder
Coleman JRI et al. “The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.” Biological Psychiatry 88(2):169-184 (2020)
Allele C
OR 1.04
p 1.0e-16
N 625,026
Large GWAS
European
intelligence
Savage JE et al. “Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.” Nature Genetics 50(7):912-919 (2018)
Allele T
OR 8.29
p 1.0e-16
N 269,867
Meta-analysisLarge GWAS
European
hip circumference
Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)
Allele T
OR 0.02
p 4.0e-11
N 143,480
Large GWAS
multi-ancestry
educational attainment, major depressive disorder
Chen D et al. “Unraveling shared susceptibility loci and Mendelian genetic associations linking educational attainment with multiple neuropsychiatric disorders.” Frontiers in Psychiatry 14:1303430 (2023)
Allele T
OR —
p 4.0e-10
N 436,988
Large GWAS
European
physical activity measurement, body mass index
Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele C
OR 0.03
p 8.0e-10
N 161,368
Meta-analysisLarge GWAS
multi-ancestry
waist circumference
Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)
Allele T
OR 0.03
p 2.0e-10
N 143,480
Large GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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