rs61765646

This is a intron variant variant in the NEGR1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

obesity

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele T

OR 0.05

p 3.0e-16

N 585,585

Major Consortium StudyLarge GWAS

multi-ancestry

heart rate response to recovery post exercise

Verweij N et al. “Genetic study links components of the autonomous nervous system to heart-rate profile during exercise.” Nature Communications 9(1):898 (2018)

Allele T

OR 0.06

p 1.0e-13

N 58,818

Large GWAS

multi-ancestry

About NEGR1

Predicted to be involved in cell adhesion and regulation of synapse assembly. Predicted to act upstream of or within several processes, including cholesterol homeostasis; lipid droplet formation; and nervous system development. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in postsynaptic density. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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