rs2605100

This is a intergenic variant variant in the LYPLAL1-AS1 gene.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Umbilical hernia

Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)
Allele A
OR 1.20
p 1.0e-15
N 275,546
Major Consortium StudyLarge GWAS
European

osteoarthritis, knee, body mass index

Zhang L et al. “A sex- and site-specific relationship between body mass index and osteoarthritis: evidence from observational and genetic analyses.” Osteoarthritis and Cartilage 31(6):819-828 (2023)
Allele A
OR —
p 1.0e-12
N 1,202,888
Large GWAS
European

pulse pressure measurement

Surendran P et al. “Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.” Nature Genetics 52(12):1314-1332 (2020)
Allele A
OR 0.12
p 1.0e-12
N 1,164,961
Meta-analysisLarge GWAS
European

Inguinal hernia

Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)
Allele A
OR 1.08
p 7.0e-10
N 275,546
Major Consortium StudyLarge GWAS
European

obesity

Lindgren CM et al. “Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.” Plos Genetics 5(6):e1000508 (2009)
Allele G
OR 0.04
p 3.0e-8
N 38,580
Meta-analysisLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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