Trait
SNPs associated with Osteoarthritis, Hip, Osteoarthritis, Knee, Total Joint Arthroplasty
109 genetic variants across 26 genes have been associated with Osteoarthritis, Hip, Osteoarthritis, Knee, Total Joint Arthroplasty in published research. Key genes include ACAN, ADAMTSL3, APOE.
Associated variants109 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs2521349 | MAP2K6 | GWAS association (p=2.0e-30) | Large GWAS |
| rs3755384 | TGFA | GWAS association (p=9.0e-27) | Large GWAS |
| rs1421085 | FTO | GWAS association (p=9.0e-25) | Large GWAS |
| rs2302417 | — | GWAS association (p=4.0e-24) | Large GWAS |
| rs28685250 | — | GWAS association (p=2.0e-23) | Large GWAS |
| rs11724531 | — | GWAS association (p=3.0e-23) | Large GWAS |
| rs6060355 | — | GWAS association (p=2.0e-22) | Large GWAS |
| rs10846653 | — | GWAS association (p=2.0e-21) | Large GWAS |
| rs12195339 | SUPT3H | GWAS association (p=2.0e-21) | Large GWAS |
| rs10843013 | — | GWAS association (p=3.0e-21) | Large GWAS |
| rs12209223 | — | GWAS association (p=9.0e-21) | Large GWAS |
| rs10484578 | — | GWAS association (p=4.0e-20) | Large GWAS |
| rs1895062 | — | GWAS association (p=5.0e-19) | Large GWAS |
| rs12047271 | — | GWAS association (p=7.0e-19) | Large GWAS |
| rs11731421 | — | GWAS association (p=2.0e-18) | Large GWAS |
| rs737142 | — | GWAS association (p=3.0e-18) | Large GWAS |
| rs12131794 | — | GWAS association (p=8.0e-18) | Large GWAS |
| rs4098282 | — | GWAS association (p=2.0e-17) | Large GWAS |
| rs4776880 | — | GWAS association (p=8.0e-17) | Large GWAS |
| rs75621460 | — | GWAS association (p=2.0e-16) | Large GWAS |
| rs4511370 | — | GWAS association (p=1.0e-15) | Large GWAS |
| rs11911487 | — | GWAS association (p=3.0e-15) | Large GWAS |
| rs2605100 | LYPLAL1-AS1 | GWAS association (p=4.0e-15) | Large GWAS |
| rs8096658 | — | GWAS association (p=4.0e-15) | Large GWAS |
| rs6327 | — | GWAS association (p=5.0e-15) | Large GWAS |
| rs1152620 | — | GWAS association (p=6.0e-15) | Large GWAS |
| rs1530586 | — | GWAS association (p=3.0e-14) | Large GWAS |
| rs10831477 | — | GWAS association (p=3.0e-14) | Large GWAS |
| rs429358 | APOE | GWAS association (p=4.0e-14) | Large GWAS |
| rs76078245 | — | GWAS association (p=5.0e-14) | Large GWAS |
| rs1809889 | — | GWAS association (p=6.0e-14) | Large GWAS |
| rs13215163 | — | GWAS association (p=1.0e-13) | Large GWAS |
| rs12350099 | — | GWAS association (p=4.0e-13) | Large GWAS |
| rs11738946 | — | GWAS association (p=5.0e-13) | Large GWAS |
| rs10859582 | — | GWAS association (p=6.0e-13) | Large GWAS |
| rs476330 | — | GWAS association (p=7.0e-13) | Large GWAS |
| rs72799257 | — | GWAS association (p=1.0e-12) | Large GWAS |
| rs10797923 | — | GWAS association (p=2.0e-12) | Large GWAS |
| rs4960263 | — | GWAS association (p=2.0e-12) | Large GWAS |
| rs4985501 | — | GWAS association (p=2.0e-12) | Large GWAS |
| rs1426371 | WSCD2 | GWAS association (p=3.0e-12) | Large GWAS |
| rs10831475 | — | GWAS association (p=6.0e-12) | Large GWAS |
| rs79752115 | — | GWAS association (p=6.0e-12) | Large GWAS |
| rs6488868 | — | GWAS association (p=6.0e-12) | Large GWAS |
| rs13135092 | — | GWAS association (p=6.0e-12) | Large GWAS |
| rs1964521 | — | GWAS association (p=7.0e-12) | Large GWAS |
| rs11497798 | — | GWAS association (p=8.0e-12) | Large GWAS |
| rs913671 | — | GWAS association (p=1.0e-11) | Large GWAS |
| rs11764536 | — | GWAS association (p=1.0e-11) | Large GWAS |
| rs7539021 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs8029440 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs5750495 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs702814 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs2936427 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs9853158 | — | GWAS association (p=3.0e-11) | Large GWAS |
| rs17566944 | — | GWAS association (p=5.0e-11) | Large GWAS |
| rs77165542 | — | GWAS association (p=6.0e-11) | Large GWAS |
| rs17677555 | — | GWAS association (p=6.0e-11) | Large GWAS |
| rs7097177 | — | GWAS association (p=9.0e-11) | Large GWAS |
| rs72758640 | — | GWAS association (p=9.0e-11) | Large GWAS |
| rs2430740 | — | GWAS association (p=9.0e-11) | Large GWAS |
| rs28929474 | SERPINA1 | GWAS association (p=1.0e-10) | Large GWAS |
| rs10971930 | DCAF12 | GWAS association (p=1.0e-10) | Large GWAS |
| rs7221010 | — | GWAS association (p=1.0e-10) | Large GWAS |
| rs2248799 | — | GWAS association (p=1.0e-10) | Large GWAS |
| rs73382475 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs7792176 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs4886410 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs3116615 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs7754762 | ESR1 | GWAS association (p=3.0e-10) | Large GWAS |
| rs79120566 | — | GWAS association (p=3.0e-10) | Large GWAS |
| rs7020944 | PAPPA | GWAS association (p=4.0e-10) | Large GWAS |
| rs2038740 | — | GWAS association (p=6.0e-10) | Large GWAS |
| rs10987385 | — | GWAS association (p=6.0e-10) | Large GWAS |
| rs4974126 | ERC2 | GWAS association (p=6.0e-10) | Large GWAS |
| rs75686861 | — | GWAS association (p=7.0e-10) | Large GWAS |
| rs79723785 | BRSK1 | GWAS association (p=8.0e-10) | Large GWAS |
| rs899927 | ADAMTSL3 | GWAS association (p=9.0e-10) | Large GWAS |
| rs9905128 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs112635299 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs11740208 | SYNPO | GWAS association (p=1.0e-09) | Large GWAS |
| rs5766632 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs6596529 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs7216323 | CASC17 | GWAS association (p=1.0e-09) | Large GWAS |
| rs3824488 | PTCH1 | GWAS association (p=1.0e-09) | Large GWAS |
| rs227732 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs76340814 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs112384186 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs6476839 | GLIS3 | GWAS association (p=2.0e-09) | Large GWAS |
| rs116614890 | PLOD2 | GWAS association (p=4.0e-09) | Large GWAS |
| rs13043476 | ZBTB46 | GWAS association (p=4.0e-09) | Large GWAS |
| rs7814941 | GSDMC | GWAS association (p=5.0e-09) | Large GWAS |
| rs9892622 | — | GWAS association (p=5.0e-09) | Large GWAS |
| rs2675228 | — | GWAS association (p=5.0e-09) | Large GWAS |
| rs112853802 | — | GWAS association (p=6.0e-09) | Large GWAS |
| rs67641990 | — | GWAS association (p=6.0e-09) | Large GWAS |
| rs1330356 | TNC | GWAS association (p=6.0e-09) | Large GWAS |
| rs116934101 | — | GWAS association (p=7.0e-09) | Large GWAS |
| rs869400 | ETV5 | GWAS association (p=7.0e-09) | Large GWAS |
| rs884205 | TNFRSF11A | GWAS association (p=7.0e-09) | Large GWAS |
Showing the top 100 of 109 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.