rs10843013
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
osteoarthritis, hip, total hip arthroplasty
Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele A
OR 0.87
p 5.0e-57
N 1,031,046
Large GWAS
multi-ancestry
osteoarthritis, hip
Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele A
OR 0.92
p 1.0e-41
N 1,152,707
Large GWAS
multi-ancestry
Styrkarsdottir U et al. “Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.” Nature Genetics 50(12):1681-1687 (2018)
Allele A
OR 1.14
p 5.0e-19
N 613,790
Meta-analysisLarge GWAS
European
Casalone E et al. “A novel variant in GLIS3 is associated with osteoarthritis.” Annals of the Rheumatic Diseases 77(4):620-623 (2018)
Allele A
OR 1.04
p 4.0e-8
N 12,456
Large GWAS
European
total hip arthroplasty, osteoarthritis
Boer CG et al. “Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.” Cell 184(18):4784-4818.e17 (2021)
Allele A
OR 0.86
p 3.0e-30
N 319,037
Large GWAS
European
osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty
Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele A
OR 0.93
p 3.0e-21
N 866,417
Large GWAS
multi-ancestry
hip geometry
Faber BG et al. “The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.” Human Molecular Genetics 34(3):207-217 (2025)
Allele A
OR 0.06
p 5.0e-14
N 43,485
Large GWAS
multi-ancestry
osteoarthritis, hip, osteoarthritis, knee
Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele A
OR 0.97
p 2.0e-11
N 1,294,321
Large GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…